John M. Tarbell
Education
B.S., Chemical Engineering, 1969,
M.S., Chemical Engineering, 1972,
Ph.D., Chemical Engineering, 1974,
Awards & Honors
Tau Beta Pi (1969), Phi Lambda Upsilon (1969), Sigma Xi (1979), National Research Service Award PHS (1983), Outstanding Teacher Award (College of Engineering 1987), Outstanding Research Award (College of Engineering 1988), Teacher of the Year (Department of Chemical Engineering, 1992), Editorial Boards: Journal of Biomechanical Engineering (1989-1995), Annals of Biomedical Engineering (1999-), Chairman of Biofluid Mechanics National Program Committee (ASME), 1989-1992, NIH Surgery and Bioengineering Study Section Member 1995-1999, Fellow of the American Institute of Medical and Biological Engineering (1996), Premier Research Award (College of Engineering, 1996), Distinguished Professor of Chemical Engineering and Bioengineering (PSU, 1998), AIMBE Board of Directors (1999), Fellow of the American Society of Mechanical Engineers (2001), President of the Biomedical Engineering Society (2002-2003), CUNY and Wallace Coulter Distinguished Professor of Biomedical Engineering (CCNY, 2003), Lissner Award from the Bioengineering Division of ASME (2004), Fellow of the Biomedical Engineering Society (2005).
Research Interests
Dr. Tarbell's current research interests fall into four basic areas: (1) effects of fluid mechanical forces on endothelial cells and smooth muscle cells, (2) in vitro studies of endothelial permeability, (3) mass transfer in the artery wall, and (4) cardiovascular fluid mechanics.
Tarbell
Lab Website
Cardiovascular Dynamics and Biomolecular Transport Laboratory
Recent Publications
Tada S, Dong C,
Tarbell JM. Effect
of the stress phase angle on the strain energy density of the endothelial
plasma membrane.
Biophys J. 2007 Nov 1;93(9):3026-33.
Dancu MB, Berardi
DE, Vanden Heuvel JP, Tarbell JM. Atherogenic Endothelial
Cell eNOS and ET-1 Responses to Asynchronous Hemodynamics are Mitigated by
Conjugated Linoleic Acid. Ann Biomed
Cancel LM, Fitting A, Tarbell
JM. In Vitro Study of LDL Transport Under Pressurized
(Convective) Conditions. Am J Physiol Heart Circ Physiol. 2007 Feb 23.
Garanich JS,
Weinbaum S,
Tarbell JM, Damiano ER. The Structure and Function of the
Endothelial Glycocalyx Layer. Annu
Rev Biomed
Pahakis MY, Kosky
JR, Dull RO, Tarbell JM.The
role of endothelial glycocalyx components in mechanotransduction of fluid shear stress. Biochem Biophys Res Commun.
2007 Mar 30;355(1):228-33.
Tada S, Tarbell
JM. Oxygen mass transport in a compliant carotid bifurcation
model. Ann Biomed
Dancu MB, Tarbell
JM. Coronary endothelium expresses a pathologic gene pattern compared to aortic
endothelium: Correlation of asynchronous hemodynamics
and pathology in vivo. Atherosclerosis. 2006 Jun 23
Dancu MB, Tarbell
JM. Large Negative Stress Phase Angle (SPA) attenuates nitric oxide production
in bovine aortic endothelial cells. J Biomech
Tarbell JM, Pahakis MY. Mechanotransduction and the glycocalyx. J Intern
Med. 2006 Apr;259(4):339-50. Review.
Garanich JS, Pahakis
M, Tarbell JM. Shear
stress inhibits smooth muscle cell migration via the nitric oxide-mediated downregulation of matrix metalloproteinase-2 activity. Am J
Physiol Heart Circ Physiol.
2005 May;288(5):H2244-52.
Tarbell JM, Weinbaum
S, Kamm RD. Cellular fluid mechanics and mechanotransduction. Ann Biomed
Tada S, Tarbell
JM. A computational study of flow in a compliant carotid bifurcation-stress
phase angle correlation with shear stress. Ann Biomed Eng.
2005 Sep;33(9):1202-12.
Pang Z,
Antonetti DA, Tarbell JM. Shear
stress regulates HUVEC hydraulic conductivity by occludin
phosphorylation. Ann Biomed
Kim MH, Harris NR, Tarbell
JM. Regulation of hydraulic conductivity in response to
sustained changes in pressure. Am J Physiol
Heart Circ Physiol. 2005 Aug 19.
Kim MH, Harris NR, Tarbell
JM. Regulation of capillary hydraulic conductivity in
response to an acute change in shear. Am J Physiol
Heart Circ Physiol. 2005 Jul 1.
Ainslie KM, Garanich
JS, Dull RO, Tarbell JM. Vascular smooth muscle cell glycocalyx influences shear stress-mediated contractile
response. J Appl Physiol.
2005 Jan;98(1):242-9.
Ainslie KM, Shi ZD, Garanich
JS, Tarbell JM. Rat aortic smooth
muscle cells contract in response to serum and its components in a calcium
independent manner. Ann Biomed
Tada S, Tarbell
JM. Internal elastic lamina affects the distribution of macromolecules in the
arterial wall: a computational study. Am J Physiol
Heart Circ Physiol. 2004 Aug;287(2):H905-13.
Kim MH, Harris NR, Korzick DH, Tarbell JM. Control of the arteriolar myogenic
response by transvascular fluid filtration. Microvasc Res.68(1):30-7. (2004)
Thi MM, Tarbell
JM, Weinbaum S,
Dancu MB, Berardi
DE, Vanden Heuvel JP, Tarbell JM. Asynchronous Shear Stress and Circumferential
Strain Reduces Endothelial NO Synthase and
Cyclooxygenase-2 but Induces Endothelin-1 Gene Expression in Endothelial Cells.
Arterioscler Thromb Vasc Biol. 2004 Sep 2
DeMaio L, Antonetti DA, Scaduto RC Jr, Gardner TW, Tarbell JM. VEGF increases paracellular transport without altering the solvent-drag
reflection coefficient. Microvasc Res. 2004 Nov;68(3):295-302.
DeMaio L, Tarbell JM, Schwartz CJ, Gardner TW, Antonetti
DA. A Transmural Pressure Gradient Induces Mechanical and
Biological Adaptive Responses in Endothelial Cells. American Journal of
Physiology: Heart and Circulatory Physiology. 2004;286:H731-H741.
John M. Tarbell
CUNY and Wallace Coulter Distinguished Professor of Biomedical Engineering
The City College of The City University of New York
Steinman Hall, T-404B
212.650.6841
212.650.6727
tarbell@ccny.cuny.edu
Tarbell Lab [..]