Luis Cardoso

Luis Cardoso

Education

Postdoc, Department of Orthopaedics, Mount Sinai School of Medicine, New York, NY 2004-2005
Ph.D., Biomechanics, Paris University, France, 2003
Master, Biomechanics, Paris University, France, 1999
B.S., Biomedical Engineering, National Polytechnic Institute, Mexico City, Mexico, 1996

Research Interests

Research in bone quality, integrating musculoskeletal biomechanics, signal/images processing, bioinstrumentation and mechanotransduction in bone.
Research in bone biomechanics includes studies of bone mineral density, microarchitecture and bone tissue quality at the microscopic and macroscopic levels. Experimental, theoretical and numerical approaches are combined for this purpose.
Bone mechanical properties are evaluated from analysis of 3D images of cancellous bone, ultrasound wave propagation, mechanical tests and Finite Element Modeling. In particular, we are interested in assessing changes in the mechanical properties of cancellous bone after disuse with and without anti-resorptive therapy using ultrasound and 3D images from microCT scanning.
Design of an Ultrasound device for assessment of bone quality ex vivo and in vivo.
Theoretical studies in poroelasticity and the interaction between wave propagation and porous media
Mechanotransduction of osteocytes in bone using animal model

Recent & Frequently Cited Publications

Peer reviewed publications

Cardoso L and Weinbaum S., "Changing Views of the Biomechanics of Vulnerable Plaque Rupture, a Review" Ann Biomed Eng. 2013 Jul 11. [Epub ahead of print]
• Cowin SC & Cardoso L. Difficulties with different approaches to the development of models for saturated poroelastic media. ZAMM • Z. Angew. Math. Mech., 1 – 11 (2013) / DOI 10.1002/zamm.201200086
• Palacio-Mancheno, P E; Larriera, A I; Cardoso, L; Fritton, S P, 3D assessment of cortical bone porosity and tissue mineral density using high-resolution micro-CT: Effects of resolution and threshold method. J Bone Miner Res. 2013 Jun 15. doi: 10.1002/jbmr.2012. [Epub ahead of print]
• Kelly-Arnold, A; Maldonado, N; Laudier, D; Aikawa, E; Cardoso, L; & Weinbaum, S., "Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries", Proc Nat Acad Sci USA, 110(26):10741-10746; published ahead of print June 3, 2013, doi: 10.1073/pnas.1308814110 2013.
• Wu Y, Sun H, Basta-Pljakic J, Cardoso L, Kennedy OD, Jasper H, Domené H, Karabatas L, Guida C, Schaffler MB, Rosen CJ, Yakar S. "Serum IGF-1 is insufficient to restore body size in the absence of the growth hormone receptor". J Bone Miner Res. 2013 Jul;28(7):1575-86. doi: 10.1002/jbmr.1920.
Cardoso, L; Fritton, S; Benalla, M; Gailani, G., Cowin SC. "Advances in assessment of bone porosity, permeability and interstitial fluid flow" Journal of Biomechanics, 2013 Jan 18;46(2):253-65. doi: 10.1016/j.jbiomech.2012.10.025. Epub 2012 Nov 19
• Souzanchi, M F; Cardoso L and Cowin SC. "Tortuosity and the averaging of micro-velocity fields in poroelasticity", Journal of Applied Mechanics, J. Appl. Mech. 80(2), 020906 (Feb 04, 2013) (5 pages) doi:10.1115/1.4007923
• Maldonado N, Kelly-Arnold A, Cardoso L, Weinbaum S. "The explosive growth of voids in vulnerable cap rupture". Journal of Biomechanics, 2013 Jan 18;46(2):396-401. doi: 10.1016/j.jbiomech.2012.10.040. Epub 2012 Dec 6
• Moesen, M, Cardoso L, Stephen C. Cowin. "A symmetry invariant formulation of the relationship between the elasticity tensor and the fabric tensor." Mechanics of Materials, 2012 Nov (54), pp. 70-83, doi:10.1016/j.mechmat.2012.07.004
• Maldonado N, Kelly-Arnold A, Vengrenyuk Y, Laudier D, Fallon JT, Virmani R, Cardoso L, Weinbaum S. "A mechanistic analysis of the role of microcalcifications in atherosclerotic plaque stability: potential implications for plaque rupture." American Journal Physiology Heart and Circulation Physiology. 2012 Sep 1;303(5):H619-28. doi: 10.1152/ajpheart.00036.2012. Epub 2012 Jul 9.
• Souzanchi, MF; Palacio Mancheno, PE; Borisov, YA; Cardoso L and Cowin SC. "Local Variations of Fabric Anisotropy and Microarchitecture in the Human Calcaneus", J. Bone Min Res. 2012 Jul 13. doi: 10.1002/jbmr.1710. [Epub ahead of print].
• Gu XI, Palacio-Mancheno PE, Leong DJ, Williams E, Maldonado N, Li YH, Laudier D, Majeska RJ, Schaffler MB, Sun HB, Cardoso L, "High resolution micro arthrography of hard and soft tissues in a murine model", Osteoarthritis and cartilage, 2012 Sep;20(9):1011-9. Epub 2012 May 18.
• Rambhia SH, Liang X, Xenos M, Alemu Y, Maldonado N, Kelly A, Chakraborti S, Weinbaum S, Cardoso L, Einav S, Bluestein D. Microcalcifications Increase Coronary Vulnerable Plaque Rupture Potential: A Patient-Based Micro-CT Fluid-Structure Interaction Study. Ann Biomed Eng. 2012 Jul;40(7):1443-54. Epub 2012 Jan 11.
• Cowin SC and Cardoso L. “Mixture theory-based poroelasticity as a model of interstitial tissue growth”, Mechanics of Materials, (July 2011) doi:10.1016/j.mechmat.2011.07.005.
Cardoso L and Cowin S. C. "Role of the structural anisotropy of biological tissues on poroelastic wave propagation ". Mechanics of Materials. (August 2011) doi:10.1016/j.mechmat.2011.08.007
• Benalla, M. Cardoso, L. and Cowin S.C. "Analytical Basis for the Determination of the Lacunar-Canalicular Permeability of Bone Using Cyclic Loading", BMMB, 2011 Sep 30. [Epub ahead of print].
• Sun, HB., Cardoso, L. and Yokota, H. "Mechanical intervention for maintenance of cartilage and bone", Clinical Medicine Arthritis and Musculoskeletal Disorders, Clin Med Insights Arthritis Musculoskelet Disord. 2011;4:65-70. Epub 2011 Jun 29.
• Elis, S., Wu, Y., Courtland, HW., Cannata, D., Sun, HB., Beth-On, M., Cardoso, L., Rosen, CJ., and Yakar, S. "Unbound (bioavailable) IGF-1 enhances somatic growth", Dis Model Mech. 2011 Sep-Oct;4(5):649-58. Epub 2011 May 31
Cardoso L. and Cowin S.C. “Fabric dependence of quasi waves in anisotropic porous media”. J. Acoust Soc. America, Vol. 29, No. 5 (2011), pp 3302-3316.
• Cowin SC & Cardoso, L; “Fabric Dependence of bone ultrasound” Acta of Bioengineering and Biomechanics, Vol. 12, No. 2 (2010), pp 3-23.
• Leong, D.J; Li Y.H; Gu X.I; Sun, Li; Zhou Z; Nasser, Ph; Laudier, D.M; Iqbal, J; Majeska 3, R.J; Schaffler M.B; Goldring, 2, M.B; Cardoso, L; Zaidi, M; Sun, H.B. “Physiologic loading of joints prevents cartilage degradation through CITED2”, FASEBJ, Vol. 25, No. 1 (2010), pp 182-191.
• Rosenberger, A.L., Cooke S.B., Rimoli R., Ni X., Cardoso L. “First skull of Antillothrix bernensis, an extinct relict monkey from the Dominican Republic”. Proceedings of the Royal Society B, Vol. 278, No. 1702 (2010), pp 67-74, July 21st, 2010, doi: 10.1098/rspb.2010.1249
• Herman, B.C; Cardoso, L; Majeska, R.J; Jepsen K.J. and Schaffler, M.B. “Activation of bone remodeling after fatigue: Differential response to linear microcracks and diffuse damage”, Bone, Vol. 47, No. 4 (2010), pp 766-772.
• Cowin SC & Cardoso, L; “Fabric Dependence of wave propagation in anisotropic porous media”. Biomechanics and modeling in Mechanobiology, Vol. 10, No. 1 (2011), pp 39-65. (Epub May 12, 2010) PMID 20461539. DOI 10.1007/s10237-010-0217-7
• Vengrenyuk, Y; Kaplan, T.J; Cardoso, L; Randolph, G.J; Weinbaum, S. “Computational stress analysis of atherosclerotic plaques in ApoE knockout mice”, Annals of Biomedical Engineering , Vol. 38, No. 3 (2010), pp 738-747 DOI: 10.1007/s10439-009-9897-5.
• Leong D.J; Gu X; Lee J.Y; Li Y; Mahammud R; Majeska R.J; Cardoso L; and Sun H.B. “Matrix Metalloproteinase-3 In Articular Cartilage Is Upregulated By Joint Immobilization And Suppressed By Passive Joint Motion" Matrix Biology, Vol. 29, No. 5 (2010), pp 420-426. Feb 12 2010 PMID:20153826.
• Gu X, Leong D.J; Lee J.Y; Li Y; Mahammud R; Majeska R.J; Cardoso L; and Sun H.B. “Development and Validation of a Motion Loading System for a rat knee joint in vivo”, Annals of Biomedical Engineering. Vol. 38, No. 3 (2010), pp 621-631. DOI: 10.1007/s10439-009-9865-0
• Gailani G; Benalla M; Mahamud R; Cowin S.C; and Cardoso L. “Experimental Determination of the Permeability in the Lacunar-Canalicular Porosity of Bone” J Biomech Eng. Vol 131, No. 9 (2009), pp. 1-8.
Cardoso L, Herman B.C; Verborgt O; Laudier D; Majeska R.J; and Schaffler M.B. “Osteocyte Apoptosis Controls Activation of Intracortical Resorption in Response to Bone Fatigue” J Bone Miner Res. 2008 Dec 2 Journal of bone and Mineral Research, Vol. 24, No. 4 (2009), pp 597-605.
Cardoso, L; Meunier, A. and Oddou, C. “In vitro acoustic wave propagation in human and bovine cancellous bone as predicted by the Biot’s theory”. Journal of Mechanics in Medicine and Biology, Vol. 8, No. 2 (2008), pp.1-19
• Vengrenyuk, Y; Cardoso, L. and Weinbaum, S. “Micro-CT Based Analysis of a New Paradigm for Vulnerable Plaque Rupture: Cellular Microcalcifications in Fibrous Caps” Molecular & Cellular Biomechanics, Special issue in honor of Prof. Y. C. Fung’s 90th Anniversary, Vol. 5, No. 1 (2008), pp. 37-48
• Choi, B.G; Vilahur, G. Cardoso, L. Fritton, J.C; Ibanez, B; Zafar, M.U; Yadegar, D; Speidl, W.S; Schaffler, M.B; Fuster, V; and Badimon J.J. “Ovariectomy increases vascular calcification via the OPG/RANKL cytokine signalling pathway”. Eur J Clin Invest; Vol 38, No. 4 (2008), 211–217
• Choi, B.G; Vilahur, G; Zafar, M.U; Cardoso, L; Yadegar, D; Ibanez, B; Tunstead, J; Viles-Gonzalez, J.F; Schaffler, M.B; Fuster, V; and Badimon, J.J. “Selective estrogen receptor modulation influences atherosclerotic plaque composition in a rabbit menopause model” Atherosclerosis Vol. 201, No. 1 (2008), pp 76-84.
• Vengrenyuk, Y; Carlier, S; Xanthos, S; Cardoso, L; Ganatos, P; Virmani, R; Einav, Sh; Gilchrist, L; and Weinbaum S. “A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous caps” PNAS Vol. 103 (2006), pp14678-14683.
• Zaidi M; Sun L; Zhang Z; Iqbal J; Zaidi S; Papachristou D; Zhou H; Sharrow A; Peng Y; Yaroslavskiy B; Zhu L; Zallone A; Sairam R; Kumar T; Cardoso-Landa L; Schaffler M.B; Moonga B; and Blair H. “FSH Directly Regulates Bone Mass. Implications for Understanding the Pathogenesis of Osteoporosis Due to Hypogonadism”. Cell, Vol. 125, No. 2 (2006), pp247-60.
Cardoso, L., Teboul, F., Sedel, L., Meunier, A. and Oddou, C. “In Vitro Acoustic Waves Propagation in Human and Bovine Cancellous Bone.” Journal of Bone and Mineral Research Vol. 18, No. 10 (2003), pp1803-12.
Cardoso, L., Teboul, F., Meunier, A. and Oddou, C. “Ultrasound Characterization of Cancellous Bone: Theoretical and Experimental analysis”. Transactions of the Ultrasonics Symposium, Vol. 2 (2001), pp1213-16.

Peer reviewed conferences

• Adreanne A. Kelly-Arnold, Natalia Maldonado, Damien Laudier,; John T. Fallon III, Renu Virmani, Luis Cardoso, Sheldon Weinbaum. "The Evolution of Calcification and the Formation of Vulnerable Plaques", The 7th International Symposium on Biomechanics in Vascular Biology and Cardiovascular Disease, April 25-27, 2012, Atlanta, GA.
• Benalla, M; Cardoso, L; Cowin, SC. "Lacunar-Canalicular Permeability of Bone Determined by harmonic Loading" 2012 Orthopaedic Research Society meeting, February 4 - 7, 2012 San Francisco, CA.
• Gu, X; Palacio-Mancheno, PE; Leong, D; Laudier, D; Majeska, RJ; Schaffler, MB; Sun, HB; and Cardoso, L. " Ultra-high Resolution micro-Arthrography Approach to Accessing Cartilage Thickness in a Murine Model ", 2012 Orthopaedic Research Society meeting, February 4 - 7, 2012 San Francisco, CA.
• Souzanchi et al. The Microstructure of the Human Calcaneus and its Effect on Anisotropic Poroelastic Ultrasound, 2012 Orthopaedic Research Society meeting, February 4 - 7, 2012 San Francisco, CA.
Cardoso L. "Imaging of Human Fibroatheromas and microcalcifications" Invited Lecture (Prof. Olivia Graeve). Society of Hispanic Professional Engineers, October 26-30, 2011, Anaheim Convention Center, Anaheim, CA
• Palacio-Mancheno, PE; Bajaj, D; Schaffler, MB; Cardoso, L; and Fritton, JC. "Partial Preservation and Restoration of Bone Lost to Disuse with Bisphosphonate and Remobilization", 2011 Annual meeting of the Biomedical Engineering Society, October 12 - 15, Hartford, CT.
• Palacio-Mancheno, PE; Borisov, Y, Souzanchi, M, Cowin SC, and Cardoso, L. " In-vitro Evidence of Fast and Slow Wave Propagation in the Human Calcaneus ", 2011 Annual meeting of the Biomedical Engineering Society, October 12 - 15, Hartford, CT.
• Gu, X; Palacio-Mancheno, PE; Leong, D; Laudier, D; Majeska, RJ; Schaffler, MB; Sun, HB; and Cardoso, L. "Ultra-high Resolution micro-Arthrography Approach to Accessing Cartilage Thickness in a Murine Model", 2011 Annual meeting of the Biomedical Engineering Society, October 12 - 15, Hartford, CT.
• Borisov, YA; Palacio Mancheno, PE; Souzanchi, MF; Cowin SC and Cardoso L. "3D Numerical Evidence of Poroelastic Wave Propagation in whole Human Calcaneus ", 2011 Annual meeting of the Biomedical Engineering Society, October 12 - 15, Hartford, CT.
• Benalla, M; Cardoso, L; Cowin, S C "Determination of the Lacunar Canalicular Permeability Using Cyclic Loading ". 2011 Annual meeting of the Biomedical Engineering Society, October 12 - 15, Hartford, CT.
• Kelly, A., Maldonado, N., Cardoso, L., Weinbaum, S., "3D Analysis of Microcalcifications in Human Vulnerable Plaques", 2011 Annual meeting of the Biomedical Engineering Society, October 12 - 15, Hartford, CT.
• Souzanchi, M; Palacio-Mancheno, PE; Borisov, YA; Cardoso, L; and Cowin, SC. "The Characterization of Local Microstructure of the Human Calcaneus", 2011 Annual meeting of the Biomedical Engineering Society, October 12 - 15, Hartford, CT.
• Maldonado, N., Kelly, A., Vengrenyuk, Y., Virmani, R., Fallon, JT., Cardoso, L., and Weinbaum, S. "Human coronary microcalcifications: 3D high resolution characterization of frequency size and distribution", 2011 ASME Summer Bioengineering Conference June 22-25, 2011, Farmington, PA.
• Kelly, A., Maldonado, N., Cardoso, L., Weinbaum, S., Vengrenyuk, Y., Fallon, JT., and Virmani, R. "Classification of Vulnerable Plaques in Human Coronary Arteries Using High Resolution Micro-CT Imaging", ASME 2011 Summer Bioengineering Conference, June 22-25, 2011, Farmington, PA
• Maldonado, N., Kelly, A., Vengrenyuk, Y., Virmani, R., Fallon, JT., Cardoso, L., and Weinbaum, S. "Three dimensional high resolution characterization of microcalcifications in human coronary arteries", 6th international symposium on Biomechanics in Vascular Biology and Cardiovascular Disease, April 14-15 2011, Rotterdam, NL.
• Kelly, A., Maldonado, N., Vengrenyuk, Y., Virmani, R., Fallon, JT., Cardoso, L., and Weinbaum, S. "Evolution of Vulnerable Plaques in Human Coronary Arteries Using High Contrast Micro-CT Imaging", 6th international symposium on Biomechanics in Vascular Biology and Cardiovascular Disease. April 14-15 2011, Rotterdam, NL.
• Benalla, M; Cardoso, L; Cowin, S C. "Lacunar-Canalicular Permeability Determination Using Harmonic Loading", 57th Annual Meeting of the Ortopaedic Research Society, January 13-16th, 2011, Long Beach, CA.
• Souzanchi, MF., Palacio-Mancheno, PE., Borisov, YA., Cardoso, L., Cowin, SC. "Local Variations of Fabric Anisotropy in the Human Calcaneus", 57th Annual Meeting of the Ortopaedic Research Society, January 13-16th, 2011, Long Beach, CA.
• Palacio-Mancheno, PE., Borisov, YA., Souzanchi, MF., Cowin, SC., Cardoso, L. "In vitro Evidence of Poroelastic Wave Propagation in the Human Calcaneus", 57th Annual Meeting of the Ortopaedic Research Society, January 13-16th, 2011, Long Beach, CA.
• Leong, D., Majeska, RJ., Zhou, Z., Xu, L., Goldring, MB., Cardoso, L., Sun, HB. " Epigallocatechin-3-gallate (EGCG) inhibits HDAC7 in chondrocytes through CITED2 ". 57th Annual Meeting of the Ortopaedic Research Society, January 13-16th, 2011, Long Beach, CA.
• Larriera, AI., Palacio Mancheno, PE., Cardoso, L., Fritton, S. " Accurate Quantification of Cortical Bone Porosity Using High-Resolution Micro-CT". 57th Annual Meeting of the Ortopaedic Research Society, January 13-16th, 2011, Long Beach, CA.
• Gu, X., Leong, D., Maldonado, N., Williams, EA., Sun, HB., Cardoso, L. " Finite Element Modeling of Rat Knee Joint for the Study of Tibio-Femoral Contact". 57th Annual Meeting of the Ortopaedic Research Society, January 13-16th, 2011, Long Beach, CA.
• Leong, D., Majeska, RJ., Xu, L., Zhou, Z., Schaffler, MB., Cardoso, L., Sun, HB. " CITED2 prevents cartilage degradation in collageninduced arthritic rats through suppression of matrix metalloproteinases" 57th Annual Meeting of the Ortopaedic Research Society, January 13-16th, 2011, Long Beach, CA.
• Cowin SC and Cardoso L. “Fabric Dependence of Poroelastic Wave Propagation” US National Congress on Theoretical and Applied Mechanics (USNCTAM) June 27 - July 2, 2010 Penn State.
• Kelly, A; Maldonado, N; Chakraborti, S; Vengrenyuk, Y; Cardoso, L; Weinbaum S, “High Contrast MicroCT Imaging of Coronary Arteries with Vulnerable Plaque for Biomechanical Modeling” Proceedings of the Biomedical Engineering Society, Austin, TX 2010.
• Maldonado, N; Kelly, A; Chakraborti, S; Vengrenyuk, Y; Cardoso, L; Weinbaum S; “Characterization of microcalcifications in coronary artery disease” Proceedings of the Biomedical Engineering Society, Austin, TX 2010.
• Gu, X; Leong, D; Maldonado N; Williams E; Sun H.B. and Cardoso, L. “The Application of Micro-CT Arthrography in 3D Geometric Reconstruction of Soft and Hard Tissues in Small Animal Joint Model”. Proceedings of the Biomedical Engineering Society, Austin, TX 2010
• Cowin SC and Cardoso L. “Ultrasound assessment of bone anisotropy using fabric-based poroelasticity: Beyond BMD”. 56th Annual Meeting of the Ortopaedic Research Society, March 6-9th, 2010, New Orleans, LA.
• Leong, D; Gu, X; Li, Y; Lee, J; Ekstein, Ch; Nasser, P; Laudier, D; Majeska, R; Schaffler, MB; Goldring, M; Cardoso, L; Sun, HB. “Downregulation of cartilage matrix metalloproteinase-3 expression by mechanical loading: evidence for CITED2 mediation in vivo and in vitro” 56th Annual Meeting of the Ortopaedic Research Society, March 6-9th, 2010, New Orleans, LA.
• Larriera, A; Sharma, D; Doty, S; Cardoso, L; Fritton, S “Using High Resolution Micro-CT to Assess Vascular Porosity Changes in Estrogen-Depleted Rat Bone” 56th Annual Meeting of the Ortopaedic Research Society, March 6-9th, 2010, New Orleans, LA.
• Gu, X; Leong, D; Sun, HB; Cardoso, L “Contrast Agent Enhanced High Resolution 3D Micro-CT Imaging of Hard and Soft Tissues in Rat Knee Joint” 56th Annual Meeting of the Ortopaedic Research Society, March 6-9th, 2010, New Orleans, LA.
Cardoso L and Cowin SC. “Fabric dependence of wave attenuation in anisotropic porous media”. 158th meeting of the Acoustical Society of America. Vol. 126 (4) April 2010. Baltimore MA.
• Cowin SC and Cardoso L. “Fabric dependence of dynamic permeability in anisotropic porous media”. 158th meeting of the Acoustical Society of America. Vol. 126 (4) April 2010. Baltimore MA.
Cardoso L. and Cowin S.C. “Anisotropic bone loss characterized using fabric-based poroelasticity”. Society for Industrial and Applied Mathematics (SIAM) annual meeting, July 6-10, 2009, Denver, CO.
• Cowin S.C. and Cardoso, L. “Fabric dependence of poroelastic wave propagation”. Society for Industrial and Applied Mathematics (SIAM) annual meeting, July 6-10, 2009, Denver, CO.
Cardoso L, and Cowin SC. “Anisotropic elastic constants of cancellous bone derived from fabric dependent poroelastic theory and ultrasound wave propagation” Proceedings of the Fourth Biot Conference on Poromechanics. DEStech publications, New York, 2009.
Cardoso L, Vengrenyuk Y, Schaffler MB and Cowin SC. “Ultrasound wave propagation in disuse induced osteoporosis” Proceedings of the Fourth Biot Conference on Poromechanics. DEStech publications, New York, 2009.
• Cowin SC and Cardoso L “Fabric dependent poroelastic wave propagation” Proceedings of the Fourth Biot Conference on Poromechanics. DEStech publications, New York 2009.
• Gailani GB, Cowin SC and Cardoso L. “Measurement of the permeability of a single osteon”. Proceedings of the Fourth Biot Conference on Poromechanics. DEStech publications, New York 2009
Cardoso L and Cowin SC. “Anisotropic bone loss characterized using fabric-based poroelasticity”. 157th meeting of the Acoustical Society of America. Vol. 125 (4) April 2009. Portland OR.
• Cowin S.C. and Cardoso L “Fabric dependence of poroelastic wave propagation”, 157th meeting of the Acoustical Society of America. Vol. 125 (4) April 2009. Portland OR.
• Gu, X; Leong, D; Mahammud, R; Li, YH; Sun HB; and Cardoso, L. “Continuous Passive Motion And Loading System Design For The Study Of Pro- & Anti-Inflamatory Mediators In Articular Cartilage”, Proceedings of the ASME 2009 Summer Bioengineering Conference (SBC2009) June 17-21, Resort at Squaw Creek, Lake Tahoe, CA, USA
• Gu, X; Leong, D; Li, YH; Shah, P; Sun, HB; Cardoso Landa, L. “Development and Validation of a Small Animal Model for Joint Biomechanics Research”. 55th Annual Meeting of the Ortopaedic Research Society, Feb 22-25th, 2009, Las Vegas, Nevada.
• Leong, D; Li, YH; Gu, X; Majeska, R; Schaffler, M; Cardoso, L; Sun, HB. “Early Changes in Articular Cartilage MMP-3 Expression in Response to Mechanical Unloading as Assessed by Laser Capture Microdissection”. 55th Annual Meeting of the Ortopaedic Research Society, Feb 22-25th, 2009, Las Vegas, Nevada.
• Gu, X; Leong, D; Li, Y.H; Guzman, F; Sun H. B; and Cardoso, L. “A Computer-Controlled Joint Loading System for Quantitative Analysis of Mechanoresponsiveness in Articular Cartilage”, Proceedings of the Junior Science Conference 2008, Vienna, Austria 2008
• Gu, X; Leong, D; Li, Y.H. Guzman, F; Sun H.B. and Cardoso, L. “In vivo Mechanical Loading System for Biomechanics Research in Cartilage”. Proceedings of the Biomedical Engineering Society, St. Louis, MO 2008
• Vengrenyuk, Y; Cardoso, L; and Weinbaum, S. “Micro-CT Based Analysis Of A New Paradigm For Vulnerable Plaque Rupture”. Fifth International Bio-Fluid Symposium and Workshop March 28-30, 2008, Pasadena, California under the Auspices of the US National Committee on Biomechanics (USNCB) The Biomedical Engineering Society (BMES) International Federation for Medical and Biological Engineering (IFMBE).
• Gailani, G. Cardoso, L. Cowin S.C. “Experimental determination of osteon permeability”. Proceedings of the ASME 2008 Summer Bioengineering Conference 2008
• Gailani, G. Cardoso, L. Cowin S.C. “Experimental determination of osteon permeability”. 9th International Bone Fluid Flow Workshop. Bone Fluid Flow, Adaptation, and Regeneration. May 22 and 23, 2008. Vrije Universiteit, Amsterdam.
• Gu, X. Leong, D. Li, Y.H. Guzman, F. Sun H.B. and Cardoso, L. “Computer-Controlled Joint Loading System For Biomechanics Research In A Rat Model”. Annual Biomedical Engineering Society Meeting 2007, Los Angeles, CA
• Vengrenyuk, Y; Schaffler M.B. and Cardoso, L. “Poroelastic media approach of ultrasound wave propagation applied to bone undergoing disuse-induced osteoporosis”. IEEE International Ultrasonic Symposium 2007, New York, NY
• Herman, B C; Laudier, D M; Cardoso-Landa, L; Zhu, L-L; Li, Y; Majeska R J; Sun, H B; Schaffler, M B “Acute osteocyte response to Fatigue Microdamage: Production of HIF-1 and VEGF-”. 53rd Annual Meeting of the Orthopaedic Research Society, Feb 11-14 2007, San Diego Cal.
• Herman, B. C.; Cardoso, L.; Majeska, R. J. and Schaffler, M B. “The Importance of Early Apoptotic Events Following Microdamage In Triggering Fatigue Induced Bone Remodeling”. 53rd Annual Meeting of the Orthopaedic Research Society, Feb 11-14 2007, San Diego Cal.
• Vengrenyuk, Y. Cardoso, L. Carlier, S.G. Einav, S. Fallon, J.T. Randolph G.J. and Weinbaum, S. “Micro-CT Based Finite Element Analysis of Atherosclerotic Plaque Stability”. 2007 Annual Biomedical Engineering Society Meeting, Los Angeles, CA
• Vengrenyuk, Y; Xanthos, S; Carlier, S; Cardoso Landa, L; Kolodgie, F; Gilchrist, L; Ganatos, P; Virmani, R; Einav Sh. and Weinbaum, S. “New hypothesis for vulnerable plaque rupture: interfacial stress concentration induced debonding of calcified macrophages in the thin fibrous cap”. 5th World congress in Biomechanics. Germany 2006
• Herman, B C; Cardoso, L; Jepsen, K J; Schaffler, M B Recovery of Stiffness Loss Following In Vivo Fatigue Loading. 52nd annual meeting of the Orthopaedic Research Society, Chicago, USA”, March 19-22, 2006
• Choi, BG; Vilahur, G; Zafar, MU; Cardoso, L; Novoselsky, CA; Yadegar, D; Bonacasa, B ; Viles-Gonzalez, JF; Schaffler, MB; Fuster, V; Badimon, JJ. "Atherosclerosis regression with selective estrogen receptor modulator therapy: an in vivo study of raloxifene by magnetic resonance imaging and micro-computed tomography”. 55th Annual Scientific Session of the American College of Cardiology. Atlanta, GA, March 2006
• Choi, BG; Vilahur, G ; M. Zafar, MU; Cardoso, L; Yadegar, D; Viles-Gonzalez, JF; Schaffler, MB; Fuster, V; Badimon, JJ. "Selective Estrogen Receptor Modulation Reduces Characteristics of Plaque Vulnerability". DOM Research Evening, the New York Academy of Medicine, May 31st 2006
• Vengrenyuk, Y; Cardoso Landa, L; Carlier, S; Andrabi1, M; Xanthos, S; Virmani, R. and Weinbaum, S. “MicroCT assessment of minute cellular level calcifications in fibrous cap as a cause of vulnerable plaque rupture”. American Heart Association meeting 2006
Cardoso, L; Laudier, D M; Majeska, R; Schaffler, M B. Inhibition of osteocyte apoptosis prevents activation of bone remodeling after fatigue in vivo. 52nd annual meeting of the Orthopaedic Research Society, Chicago, USA”, March 19-22, 2006
• Vengrenyuk, Y; Cardoso Landa, L; Carlier, S; Andrabi1, M; Xanthos, S; Virmani, R. and Weinbaum, S. “Vulnerable plaque rupture due to stress concentration around cellular level calcifications in the fibrous cap”. Annual Biomedical Engineering Society Meeting 2006, Chicago, IL
• Choi, BG; Vilahur, G; Cardoso, L; Fritton, JC; Zafar, MU; Yadegar, D; Ibanez, B; Viles-Gonzalez, JF; Schaffler, MB; Fuster, V; Badimon, JJ. “Ovariectomy increases vascular calcification via the receptor activator of nuclear factor-kB ligand/osteoprotegerin cytokine signaling pathway”. Circulation, 114 (18): 76-76 Suppl. S OCT 31 2006. ISSN: 0009-7322
• Choi, BG; Vilahur, G; Zafar, MU; Cardoso, L; Novoselsky, CA; Yadegar, D; Bonacasa, B; Viles-Gonzalez, JF; Schaffler, MB; Fuster, V; Badimon, JJ. “Atherosclerosis regression with selective estrogen receptor modulator therapy: An in vivo study of raloxifene by magnetic resonance Imaging and micro-computed tomography”. Journal of the American College of Cardiology, 47 (4): 296A-296A Suppl. A FEB 21 2006. ISSN: 0735-1097
• Choi, BG; Vilahur, G; Zafar, MU; Cardoso, L; Schaffler, MB; Fuster, V; Badimon, JJ. “Selective estrogen receptor modulation with raloxifene improves plaque stability via atheroma regression, inflammation reduction and enhanced structure of vascular calcification” European Heart Journal, 27: 458-459 Suppl. 1 AUG 2006 ISSN: 0195-668X
• Sun L, Zhang Z, Peng Y, Iqbal J, Zaidi S, Papachristou DJ, Zhou H, Sharrow AC, Yaroslavskiy BB, Zhu L, Zallone A, Sairam MR, Kumar TR, Cardoso-Landa L, Schaffler MB, Moonga BS, Blair HC, Zaidi M, “FSH directly regulates bone mass: Implications for understanding the pathogenesis of osteoporosis due to hypogonadism” Journal of Bone and Mineral Research, 20 (9): S12-S12 Suppl. 1 SEP 2005. ISSN: 0884-0431
• Zhang Z, Sun L, Peng Y, Iqbal J, Zaidi S, Papachristou DJ, Zhou H, Sharrow AC, Yaroslavskiy BB, Zhu L, Zallone A, Sairam MR, Kumar TR, Cardoso-Landa L, Schaffler MB, Moonga BS, Blair HC, Zaidi M, “The pituitary hormone, FSH, directly enhances osteoclast formation and survival.” Journal of Bone and Mineral Research, 20 (9): S26-S26 Suppl. 1 SEP 2005. ISSN: 0884-0431
Cardoso, L; Seo, S; Jepsen, K J; Oddou, C; Meunier, A; Schaffler, M B. “Structurally-based ultrasonic approach of cancellous bone characterization”. 51st annual meeting of the Orthopaedic Research Society, Washington, USA, February 20-23, 2005
Cardoso, L; Seo, S; Jepsen, K J; Oddou, C; Meunier, A; Schaffler, M B. “Ultrasonic characterization of anisotropic trabecular bone undergoing disuse osteoporosis with and without antiresorptive therapy”. 51st annual meeting of the Orthopaedic Research Society, Washington, USA, February 20-23, 2005
Cardoso, L; Seo, S; Jepsen, K J; Schaffler, M B. “Ultrasound based assessment of trabecular bone in disuse osteoporosis”. Bone Loss during Spaceflight, Cleveland, USA, June 23-24, 2005.
Cardoso, L; Meunier, A; Oddou, C. Sondage Ultrasonore et Caractérisation des Tissus Biologiques. Abstract in “Journées Extensométrie 2003, Champs-Sur-Marne, France”, 2003
Cardoso, L; Meunier, A; Oddou, C. Theoretical and Experimental Ultrasonic Characterization of Anisotropic Properties in Cancellous Bone. Abstract in “World Congress on Ultrasonics, Paris, France”, 2003
Cardoso, L; Teboul, F; Sedel, L; Oddou, C; Meunier, A. Ultrasonic characterization of human and bovine trabecular bone using Biot theory. Abstract in CD ROM “49th annual meeting of the Orthopaedic Research Society, New Orleans, USA”, February 2-5, 2003
Cardoso, L; Teboul, F; Meunier, A; Oddou, C. Theoretical and experimental approach in ultrasonic characterization of cancellous bone. Abstract in “16ème Congrès Français de Mécanique, Nice, France”, 2003
Cardoso, L; Teboul, F; Oddou, C; Meunier, A. Ultrasonic Wave Propagation in Human and Bovine Cancellous Bone. Abstract in “IUTAM Symposium on the Mechanics of Physicochemical and Electromechanical Interactions in Porous Media, Eindhoven, Netherlands”, 2003
Cardoso, L; Teboul, F; Meunier, A; Oddou, C. Dynamics of Porous Media ans Acoustical characterization of bony Tissue. Abstract in “12th International Conference on Mechanics in Medicine and Biology, Lemnos, Greece”, 2002
Cardoso, L; Teboul, F; Meunier, A; Oddou, C. Characterisation of Cancellous Human Bone Properties by Ultrasonics. “Proceedings of the 13th Conference of the European Society of Biomechanics,Wroclaw, Poland” Abstract in “Acta of Bioengineering and Biomechanics”. Vol 4, sup 1, pp 367-368, 2002
Cardoso, L; Teboul, F; Meunier, A; Oddou, C. Ultrasound Wave Propagation in Porous Medium : Application to Cancellous Bone. Abstract in CD ROM “IV World Congress of Biomechanics, Calgary, Alberta, Canada”, 2002
Cardoso, L; Teboul, F; Meunier, A; Oddou, C. Ultrasound Characterization of Cancellous Bone: Theoretical and Experimental analysis. Abstract in “2001 IEEE International Ultrasonics Symposium and the World Congress on Ultrasonics, Atlanta, Georgia”, pp125-126, 2001
Cardoso, L; Teboul, F; Meunier, A; Oddou, C. Trabecular bovine bone characterization by ultrasound. Poroelastic approach. “XXVIème Congrès de la Société de Biomécanique. Marseille, France”.Abstract in Archives of Physiology and Biochemistry Vol 109, p. 96, Suppt Sep 2001
Cardoso, L; Teboul, F; Meunier, A; Oddou, C. Acoustique des milieux poreux: Application à la caractérisation de l'os trabeculaire (Porous media acoustics. Application to the cancellous bone characterization). Abstract in CD ROM “XVème Congrès Français de Mécanique, Nancy, France. Num 311, pp1-7” 2001
Cardoso, L; Teboul, F; Meunier, A; Oddou, C. Acoustique Ultrasonore appliqué à l'Os Trabeculaire (Ultrasonic acoustics applied to cancellous bone). Abstract in “VIIème Journées d'Acoustique Physique, Sous-Marine et Ultrasonore. Marseille, France. ” 2001
• Oddou C; Cardoso L; Meunier A; Geiger D. A Critical Analysis of the Ultrasound Technique for Bone Tissue Rheological Characterization. Abstract in “The Second China-Denmark-France Symposium on Biomechanics and Biorheology. Shanghai, China.” 2000.


Luis Cardoso
Associate Professor of Biomedical Engineering The City College of The City University of New York
T-565
212.650.7154
212.650.6727
cardoso@engr.ccny.cuny.edu
Cardoso Lab [..]