Luis Cardoso

Luis Cardoso


Postdoc, Department of Orthopaedics, Mount Sinai School of Medicine, New York, NY 2004-2005

Ph.D., Biomechanics, Paris University, France, 2003

Master, Biomechanics, Paris University, France, 1999

B.S., Biomedical Engineering, National Polytechnic Institute, Mexico City, Mexico, 1996


Research Interests

Research in bone quality, integrating musculoskeletal biomechanics, signal/images processing, bioinstrumentation and mechanotransduction in bone.

Research in bone biomechanics includes studies of bone mineral density, microarchitecture and bone tissue quality at the microscopic and macroscopic levels. Experimental, theoretical and numerical approaches are combined for this purpose.

Bone mechanical properties are evaluated from analysis of 3D images of cancellous bone, ultrasound wave propagation, mechanical tests and Finite Element Modeling. In particular, we are interested in assessing changes in the mechanical properties of cancellous bone after disuse with and without anti-resorptive therapy using ultrasound and 3D images from microCT scanning.

Design of an Ultrasound device for assessment of bone quality ex vivo and in vivo.

Theoretical studies in poroelasticity and the interaction between wave propagation and porous media

Mechanotransduction of osteocytes in bone using animal model


Recent & Frequently Cited Publications

Peer reviewed publications

Maldonado N, Kelly-Arnold A, Laudier D, Weinbaum S, Cardoso L. Imaging and analysis of microcalcifications and lipid/necrotic core calcification in fibrous  cap atheroma. The international journal of cardiovascular imaging. 2015; 31(5):1079-87. PubMed [journal] PMID: 25837377 

Cowin SC, Cardoso L. Blood and interstitial flow in the hierarchical pore space architecture of bone tissue. Journal of biomechanics. 2015; 48(5):842-54. NIHMSID: NIHMS652555 PubMed [journal] PMID: 25666410, PMCID: PMC4489573 

Lobatto ME, Calcagno C, Millon A, Senders ML, Fay F, et al. Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging. ACS nano. 2015; 9(2):1837-47. NIHMSID: NIHMS702321 PubMed [journal] PMID: 25619964, PMCID: PMC4492477 

Cardoso L, Schaffler MB. Changes of elastic constants and anisotropy patterns in  trabecular bone during disuse-induced bone loss assessed by poroelastic ultrasound. Journal of biomechanical engineering. 2015; 137(1). PubMed [journal]  PMID: 25412022, PMCID: PMC4290507 

Cowin SC, Cardoso L. Difficulties arising from different definitions of tortuosity for wave propagation in saturated poroelastic media models ZAMM - Journal of Applied Mathematics and Mechanics / Zeitschrift für Angewandte  Mathematik und Mechanik. 2014 September; 94(9):694-704.

Benalla M, Palacio-Mancheno PE, Fritton SP, Cardoso L, Cowin SC. Dynamic permeability of the lacunar-canalicular system in human cortical bone. Biomechanics and modeling in mechanobiology. 2014; 13(4):801-12. NIHMSID: NIHMS533674 PubMed [journal] PMID: 24146291, PMCID: PMC3995902 

Gong Z, Kennedy O, Sun H, Wu Y, Williams GA, et al. Reductions in serum IGF-1 during aging impair health span. Aging cell. 2014; 13(3):408-18. PubMed [journal] PMID: 24341939, PMCID: PMC4326899 

Adise S, Saliu A, Maldonado N, Khatri V, Cardoso L, et al. Effect of maternal care on hearing onset induced by developmental changes in the auditory periphery. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014; 34(13):4528-33. PubMed [journal] PMID: 24671998, PMCID: PMC3965781 

Cardoso L, Kelly-Arnold A, Maldonado N, Laudier D, Weinbaum S. Effect of tissue properties, shape and orientation of microcalcifications on vulnerable cap stability using different hyperelastic constitutive models. Journal of biomechanics. 2014; 47(4):870-7. NIHMSID: NIHMS565035 PubMed [journal] PMID: 24503048, PMCID: PMC4019736 

Kennedy OD, Sun H, Wu Y, Courtland HW, Williams GA, et al. Skeletal response of male mice to anabolic hormone therapy in the absence of the Igfals gene. Endocrinology. 2014; 155(3):987-99. PubMed [journal] PMID: 24424061, PMCID: PMC3929729 

Cardoso L, Weinbaum S. Changing views of the biomechanics of vulnerable plaque rupture: a review. Annals of biomedical engineering. 2014; 42(2):415-31. NIHMSID: NIHMS504724 PubMed [journal] PMID: 23842694, PMCID: PMC3888649 

Palacio-Mancheno PE, Larriera AI, Doty SB, Cardoso L, Fritton SP. 3D assessment of cortical bone porosity and tissue mineral density using high-resolution µCT: effects of resolution and threshold method. Journal of bone and mineral research  : the official journal of the American Society for Bone and Mineral Research. 2014; 29(1):142-50. NIHMSID: NIHMS497828 PubMed [journal] PMID: 23775635, PMCID:  PMC3870034 

Shi L, Palacio-Mancheno P, Badami J, Shin da W, Zeng M, et al. Quantification of  transient increase of the blood-brain barrier permeability to macromolecules by optimized focused ultrasound combined with microbubbles. International journal of nanomedicine. 2014; 9:4437-48. PubMed [journal] PMID: 25258533, PMCID: PMC4173757 

Leong DJ, Zhang H, Xu L, Tang J, Hirsh DM, et al. Therapeutic Ultrasound: Osteoarthritis Symptom-Modification and Potential for Disease Modification J Surgery. 2013 September; 1(2):1-5.

Wu Y, Sun H, Basta-Pljakic J, Cardoso L, Kennedy OD, et al. Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone  receptor. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2013; 28(7):1575-86. NIHMSID: NIHMS451070 PubMed [journal] PMID: 23456957, PMCID: PMC3843230 

Kelly-Arnold A, Maldonado N, Laudier D, Aikawa E, Cardoso L, et al. Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries. Proceedings of the National Academy of Sciences of the United States of America.  2013; 110(26):10741-6. PubMed [journal] PMID: 23733926, PMCID: PMC3696743 

Souzanchi MF, Cardoso L, Cowin SC. Tortuosity and the Averaging of Microvelocity  Fields in Poroelasticity. Journal of applied mechanics. 2013; 80(2):0209061-209065. PubMed [journal] PMID: 24891725, PMCID: PMC3994768 

Cardoso L, Fritton SP, Gailani G, Benalla M, Cowin SC. Advances in assessment of  bone porosity, permeability and interstitial fluid flow. Journal of biomechanics. 2013; 46(2):253-65. NIHMSID: NIHMS423340 PubMed [journal] PMID: 23174418, PMCID:  PMC3735900 

Maldonado N, Kelly-Arnold A, Cardoso L, Weinbaum S. The explosive growth of small voids in vulnerable cap rupture; cavitation and interfacial debonding. Journal of biomechanics. 2013; 46(2):396-401. NIHMSID: NIHMS427695 PubMed [journal] PMID: 23218838, PMCID: PMC4019735 

Souzanchi MF, Palacio-Mancheno P, Borisov YA, Cardoso L, Cowin SC. Microarchitecture and bone quality in the human calcaneus: local variations of fabric anisotropy. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2012; 27(12):2562-72. NIHMSID: NIHMS392985 PubMed [journal] PMID: 22807141, PMCID: PMC3500573 

Moesen M, Cardoso L, Cowin SC. A symmetry invariant formulation of the relationship between the elasticity tensor and the fabric tensor. Mechanics of materials : an international journal. 2012; 54:70-83. NIHMSID: NIHMS398819 PubMed [journal] PMID: 23467780, PMCID: PMC3586311 

Maldonado N, Kelly-Arnold A, Vengrenyuk Y, Laudier D, Fallon JT, et al. A mechanistic analysis of the role of microcalcifications in atherosclerotic plaque stability: potential implications for plaque rupture. American journal of physiology. Heart and circulatory physiology. 2012; 303(5):H619-28. PubMed [journal] PMID: 22777419, PMCID: PMC3468470 

Gu XI, Palacio-Mancheno PE, Leong DJ, Borisov YA, Williams E, et al. High resolution micro arthrography of hard and soft tissues in a murine model. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2012; 20(9):1011-9. NIHMSID: NIHMS387788 PubMed [journal] PMID: 22613702, PMCID: PMC3411931 

Benalla M, Cardoso L, Cowin SC. Analytical basis for the determination of the lacunar-canalicular permeability of bone using cyclic loading. Biomechanics and modeling in mechanobiology. 2012; 11(6):767-80. PubMed [journal] PMID: 21959747 

Rambhia SH, Liang X, Xenos M, Alemu Y, Maldonado N, et al. Microcalcifications increase coronary vulnerable plaque rupture potential: a patient-based micro-CT fluid-structure interaction study. Annals of biomedical engineering. 2012; 40(7):1443-54. PubMed [journal] PMID: 22234864 

Cardoso L, Cowin SC. Role of structural anisotropy of biological tissues in poroelastic wave propagation. Mechanics of materials : an international journal.  2012; 44:174-188. NIHMSID: NIHMS320594 PubMed [journal] PMID: 22162897, PMCID: PMC3233242 

Cowin SC, Cardoso L. Mixture theory-based poroelasticity as a model of interstitial tissue growth. Mechanics of materials : an international journal. 2012; 44:47-57. NIHMSID: NIHMS321843 PubMed [journal] PMID: 22184481, PMCID: PMC3241054 

Elis S, Wu Y, Courtland HW, Cannata D, Sun H, et al. Unbound (bioavailable) IGF1  enhances somatic growth. Disease models & mechanisms. 2011; 4(5):649-58. PubMed [journal] PMID: 21628395, PMCID: PMC3180229 

Cardoso L, Cowin SC. Fabric dependence of quasi-waves in anisotropic porous media. The Journal of the Acoustical Society of America. 2011; 129(5):3302-16. PubMed [journal] PMID: 21568431, PMCID: PMC3115277 

Cowin SC, Cardoso L. Fabric dependence of wave propagation in anisotropic porous  media. Biomechanics and modeling in mechanobiology. 2011; 10(1):39-65. NIHMSID: NIHMS387851 PubMed [journal] PMID: 20461539, PMCID: PMC3393603 

Rosenberger AL, Cooke SB, Rímoli R, Ni X, Cardoso L. First skull of Antillothrix  bernensis, an extinct relict monkey from the Dominican Republic. Proceedings. Biological sciences / The Royal Society. 2011; 278(1702):67-74. PubMed [journal]  PMID: 20659936, PMCID: PMC2992729 

Leong DJ, Li YH, Gu XI, Sun L, Zhou Z, et al. Physiological loading of joints prevents cartilage degradation through CITED2. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2011; 25(1):182-91. PubMed [journal] PMID: 20826544, PMCID: PMC3005439 

Sun HB, Cardoso L, Yokota H. Mechanical intervention for maintenance of cartilage and bone. Clinical medicine insights. Arthritis and musculoskeletal disorders. 2011; 4:65-70. PubMed [journal] PMID: 21792344, PMCID: PMC3140275 

Herman BC, Cardoso L, Majeska RJ, Jepsen KJ, Schaffler MB. Activation of bone remodeling after fatigue: differential response to linear microcracks and diffuse damage. Bone. 2010; 47(4):766-72. NIHMSID: NIHMS222728 PubMed [journal] PMID: 20633708, PMCID: PMC2939191 

Leong DJ, Gu XI, Li Y, Lee JY, Laudier DM, et al. Matrix metalloproteinase-3 in articular cartilage is upregulated by joint immobilization and suppressed by passive joint motion. Matrix biology : journal of the International Society for Matrix Biology. 2010; 29(5):420-6. NIHMSID: NIHMS179415 PubMed [journal] PMID: 20153826, PMCID: PMC2902573 

Gu XI, Leong DJ, Guzman F, Mahamud R, Li YH, et al. Development and validation of a motion and loading system for a rat knee joint in vivo. Annals of biomedical engineering. 2010; 38(3):621-31. NIHMSID: NIHMS193395 PubMed [journal] PMID: 20013312, PMCID: PMC2870720 

Vengrenyuk Y, Kaplan TJ, Cardoso L, Randolph GJ, Weinbaum S. Computational stress analysis of atherosclerotic plaques in ApoE knockout mice. Annals of biomedical engineering. 2010; 38(3):738-47. PubMed [journal] PMID: 20336835 

Cowin SC, Cardoso L. Fabric dependence of bone ultrasound. Acta of bioengineering and biomechanics / Wroclaw University of Technology. 2010; 12(2):3-23. PubMed [journal] PMID: 20882938 

Gailani G, Benalla M, Mahamud R, Cowin SC, Cardoso L. Experimental determination  of the permeability in the lacunar-canalicular porosity of bone. Journal of biomechanical engineering. 2009; 131(10):101007. NIHMSID: NIHMS172490 PubMed [journal] PMID: 19831477, PMCID: PMC2821594 

Cardoso L, Herman BC, Verborgt O, Laudier D, Majeska RJ, et al. Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2009; 24(4):597-605. PubMed [journal] PMID: 19049324, PMCID: PMC2659511 

Choi BG, Vilahur G, Zafar MU, Cardoso L, Yadegar D, et al. Selective estrogen receptor modulation influences atherosclerotic plaque composition in a rabbit menopause model. Atherosclerosis. 2008; 201(1):76-84. NIHMSID: NIHMS78385 PubMed  [journal] PMID: 18367192, PMCID: PMC3387929 

In vitro acoustic wave propagation in human and bovine cancellous bone as predicted by the Biot’s theory Cardoso L, Meunie A, Oddou C. Journal of Mechanics in Medicine and Biology. 2008 June; 8(02):183-201. My Bibliography [journal]  

Choi BG, Vilahur G, Cardoso L, Fritton JC, Ibanez B, et al. Ovariectomy increases vascular calcification via the OPG/RANKL cytokine signalling pathway. European journal of clinical investigation. 2008; 38(4):211-7. PubMed [journal] PMID: 18279396 

Vengrenyuk Y, Cardoso L, Weinbaum S. Micro-CT based analysis of a new paradigm for vulnerable plaque rupture: cellular microcalcifications in fibrous caps. Molecular & cellular biomechanics : MCB. 2008; 5(1):37-47. PubMed [journal] PMID: 18524245 

Vengrenyuk Y, Carlier S, Xanthos S, Cardoso L, Ganatos P, et al. A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous caps. Proceedings of the National Academy of Sciences of the United States of America. 2006; 103(40):14678-83. PubMed [journal] PMID: 17003118, PMCID: PMC1595411 

Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, et al. FSH directly regulates bone mass. Cell. 2006; 125(2):247-60. PubMed [journal] PMID: 16630814 

Cardoso L, Teboul F, Sedel L, Oddou C, Meunier A. In vitro acoustic waves propagation in human and bovine cancellous bone. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2003; 18(10):1803-12. PubMed [journal] PMID: 14584891


Luis Cardoso
Professor of Biomedical Engineering The City College of The City University of New York
Cardoso Lab [..]