Marom Bikson
Education
Research Fellow, Neurophysiology Unit, University of Birmingham Medical School, U.K., 2003
Ph.D., Biomedical Engineering, Case Western Reserve University Cleveland, OH, 2000
B.S., Biomedical Engineering (EE Concentration), Johns Hopkins University, Baltimore, MD, 1995
Research Areas and Expertise
Prof. Marom Bikson’s research group studies the effects of electricity on the human body and applies this knowledge toward the development of medical devices and electrical safety guidelines.
| "Our goal is to improve human health by combining engineering innovation, with cutting-edge experimental techniques, and original bio-medical insight. This challenge requires creative problem-solving, precision, and imagination. We are tremendously fortunate to access the extensive resources of the City University of New York research centers and of the New York Center for Biomedical Engineering hospital network." |
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Specific areas of research include:
1) Medical devices including biosensors, drug delivery technology, and electrotherapy devices for neurological disorders.
2) Medical device safety including electrical hazards, electroporation, heating damage, and safe stimulation protocols.
3) Electrical safety, electric shock hazards, and accidental electrocution.
4) Understanding the neuronal networks underlying normal brain function, including the role of endogenous electric fields.
5) Developing new treatments for neurological diseases including epilepsy and depression, through translational research.
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Prof. Bikson’s group uses a range of research and engineering design tools including cellular and animal studies, computer simulations, imaging, and clinical evaluation. Prof. Bikson’s research has recieved support from funding agencies including NIH (NINDS,NCI,NIGMS), The Andy Grove Foundation, The Wallace H. Coulter Foundation, and the Howard Hughes Medical Institute. Prof. Bikson is co-founder and CEO of Soterix Medical Inc. . Prof. Bikson is actively involved in biomedical education including outreach to underserved groups. |
Prof. Bikson has provided technical support and consulting for biomedical companies (Medtronic, Boston Scientific, Nevrocorp, Ion Channel Innovations, Wyle), utility companies (Con Edison, First Energy), regulatory agencies (NASA, NY State Public Service Commission, Potomac Institute for Policy Studies), and litigation support.
View Prof. Bikson's CV PDF
| Prof. Bikson is co-director of Neural Engineering at The City College of New York and the New York Center for Biomedical Engineering. More project information at CCNY Neural Engineering |
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Selected Publications Search PubMed
Dasilva AF, Volz MS, Bikson M, Fregni F. Electrode positioning and montage in transcranial direct current stimulation. JOVE . 2011; (51) video
Turkeltaub PE, Benson J, Hamilton RH, Datta A, Bikson M, Coslett HB. Left lateralizing transcranial direct current improves reading efficiency. Brain Stimulation 2011; in press
Dmochowski JP, Datta A, Bikson M, Su Y, Parra LC. Optimized multi-electrode stimulation increases focality and intensity at target. Journal of Neural Engineering . 2011; 8(4) PDF
Peterchev AV, Wagner TM, Miranda PC, Nitsche MA, Paulus W, Lisanby SG, Pascual-Leone A, Bikson M. Transcranial Electric and Magnetic Stimulation Dose: Principles and Reporting. Brain Stimulation 2011; in press
Bikson M, Datta A. Guidlines for precise and accurate models of tDCS. Brain Stimulation 2011, in press . Brain Stimulation 2011; in press
Brunoni AR, Nitsche MA, Bolognini N, Bikson M et al. Clinical research with transcranial direct current stimulation (tDCS): Challenges and Future Directions. Brain Stimulation 2011; in press
Datta A, Baker J, Bikson M, Fridriksson F. Individualized model predicts brain current flow during transcranial direct-current stimulation treatment in responsive stroke patient. Brain Stimulation 2011; 4: 169-74 PDF
Halko M, Datta A, Plow E, Scaturro J, Bikson M, Merabet L. Neuroplastic changes following rehabilitative training correlate with regional electrical field induced with tDCS. NeuroImage . 2011; 57: 885-891 PDF
Mendonca ME, Santana MB, Baptista AF, Datta A, Bikson M, Fregni D, Araujo CP. Transcranial DC Stimulation in Fibromyalgia: Optimized cortical target supported by high-resolution computational models. Journal of Pain . 2011; 12(5):610-617 PDF COVER
Minhas P, Datta A, Bikson M. Cutaneous perception during tDCS: Role of electrode shape and sponge salinity. Clinical Neurophysiology . 2011; 122:637-638 PDF
Bikson M, Datta A, Elwassif M, Bansal V, Peterchev AV. Introduction to Electrotherapy Technology. in Brain Stimulation in the Treatment of Pain. ed. Helena Knotkova, Ricardo Crucianim, and Joav Merrick. Nova Science, New York 2011 ISBN 978-1-60876-690-1 PDF
Brunoni AR, Nitsche MA, Bolognini N, Bikson M et al. Clinical research with transcranial direct current stimulation (tDCS): Challenges and Future Directions Brain Stimulation . 2011; in press
Reato D, Rahman A, Bikson M, Parra L. Low-intensity electrical stimulation affects network dynamics by modulating population rate and spike timing. Journal of Neuroscience. 2010; 30(45):15067-79 PDF
Servais EL, Rizk NP,McGwyver LO, Rusch VW, Bikson M, Adusumilli PS. Real-time intraoperative detection of tissue hypoxia in gastrointestinal surgery by Wireless Pulse Oximetry (WiPOX). Surgical Endoscopy. 2010; 25(5):1383-9
Datta A, Rahman A, Scaturro J, Bikson M. Electrode montages for tDCS and weak transcranial electrical stimulation Role of "return" electrode's position and size. Clinical Neurophysiology. 2010; 121:1976-1978 PDF
Minhas P, Patel J, Bansal V, , Ho J, Datta A, Bikson M. Electrodes for high-definition transcutaneous DC stimulation for applications in drug-delivery and electrotherapy, including tDCS. Journal of Neuroscience Methods . 2010; 190(2):188-97 PDF
Datta A, Bikson M, Fregni F. Transcranial direct current stimulation in patients with skull defects and skull plates: High-resolution computational FEM study of factors altering cortical current flow. Neuroimage . 2010; 52(4):1268-78 PDF
Sunderam S, Gluckman B, Reato D, Bikson M. Toward rational design of electrical stimulation strategies for epilepsy control. Epilepsy & Behavior . 2010; 17:6-22 PDF
Lopez-Quitero SV, Datta A, Amaya R, Elwassif M, Bikson M, Tarbell JM. DBS-relevant electric fields increase hydraulic conductivity of in vitro endothelial monolayers. Journal of Neural Engineering . 2010; 7(1) PDF
Radman T, Ramos RL, Brumberg JC, Bikson M. Role of cortical cell type and morphology in sub- and suprathreshold uniform electric field stimulation. Brain Stimulation. 2009; 2(4):215-228. PDF
Datta A, Bansal V, Diaz J, Patel J, Reato D, Bikson M. Gyri –precise head model of transcranial DC stimulation: Improved spatial focality using a ring electrode versus conventional rectangular pad. Brain Stimulation. 2009; 2(4):201-207. PDF
Datta A, Elwassif M. Bikson M. Bio-heat transfer model of transcranial DC stimulation: Comparison of conventional pad versus ring electrode IEEE EMBS. 2009 PDF
Datta A, Baker J, Bikson M, Fridriksson F. Individualized model predicts brain current flow during transcranial direct-current stimulation treatment in responsive stroke patient. Brain Stimulation 2011; 4: 169-74 PDF
Bikson M, Bulow P, Stiller JW, Datta A, Battaglia F, Karnup SV, Postolache TT. Transcranial direct current stimulation for major depression: a general system for quantifying transcranial electrotherapy dosage. Current Treatment Options in Neurology. 2008; 10:377-85. PDF
Datta A, Elwassif M, Battaglia F, Bikson M. Transcranial current stimulation focality using disc and ring electrode configurations: FEM analysis. Journal of Neural Engineering. 2008; 5:163-174. PDF
An JH, Radman T, Su Y, Bikson M. Effects of glucose and glutamine concentration in the formulation of the artificial cerebrospinal fluid (ACSF). Brain Research. 2008; 1218:1586-93 PDF
Su Y, Radman T, Vaynshteyn J, Parra LC, Bikson M. Effects of high-frequency stimulation on epileptiform activity in vitro: ON/OFF control paradigm. Epilepsia. 2008; 49:1586-93 PDF
Radman T, Su Y, An JH, Parra L, Bikson M. Spike timing amplifies the effect of electric fields on neurons: Implications for endogenous field effects Journal of Neuroscience. 2007; 27:3030-3036. PDF
Fox JE, Bikson M, Jefferys JG. The effect of neuronal population size on the development of epileptiform discharges in the low calcium model of epilepsy. Neuroscience Letters. 2007; 411:158-61.
Elwassif MM, Kong Q, Vazquez M, Bikson M. Bio-heat transfer model of deep brain stimulation-induced temperature changes. Journal of Neural Engineering. 2006; 3:306-15. PDF
Merrill D, Bikson M, Jefferys JGR. Electrical stimulation of excitable tissue: design of efficacious and safe protocols. Journal of Neuroscience Methods. 2005; 141: 171-198 PDF
Fox JE, Bikson M, Jefferys JGR. Tissue resistance changes and the profile of synchronized neuronal activity during ictal events in the low calcium model of epilepsy. Journal of Neurophysiology. 2004; 92: 181-188 PDF
Bikson M, Inoue M, Akiyama H, Deans JK, Fox JE, Miyakawa H, Jefferys JGR.
Effects of uniform extracellular DC electric fields on excitability in rat hippocampal
slices in vitro. Journal of Physiology. 2004; 557: 175-190 PDF
Bikson M, Hahn PJ, Fox JE, Jefferys JGR. Depolarization block of neurons during maintenance of electrographic seizures. Journal of Neurophysiology. 2003; 90: 2402-2408 PDF
Jefferys JGR, Deans J, Bikson M, Fox J. Effects of weak electric fields on the activity of neurons and neuronal network. Radiation Protection Dosimetry. 2003; 106:321-323
Shuai J, Bikson M, Lian J, Hahn PJ, Durand DM. Ionic mechanisms underlying spontaneous CA1 neuronal firing in Ca2+-Free Solution. Biophysical Journal 2003; 84: 2099-111
Lian J, Bikson M, Sciortino C, Stacey WC, Durand DM. Local suppression of epileptiform activity by AC Fields. Journal of Physiology. 2003; 547: 427-434
Bikson M, Fox JE, Jefferys JGR. Neuronal aggregate formation underlies spatio-temporal dynamics of non-synaptic seizure initiation. Journal of Neurophysiology. 2003; 89: 2330-2331 PDF
Bikson M, Id Bihi R, Vreugdenhil M, Kohling R, Fox JE, Jefferys JGR. Quinine suppresses extracellular potassium transients and ictal epileptiform activity without decreasing neuronal excitability in vitro. Neuroscience 2002; 115: 253-263
Lian J, Bikson M, Shuai J, Durand DM. Propagation of non-synaptic epileptiform activity across lesion in rat hippocampal slices. Journal of Physiology 2001; 537; 191-199
Bikson M, Baraban SC, Durand DM. Conditions sufficient for non-synaptic epileptogenesis in the CA1 region of rat hippocampal slices. Journal of Neurophysiology 2001; 87:62-71 PDF
Bikson M, Lian J, Hahn PJ, Stacey WC, Sciortino C, Durand DM. Suppression of epileptiform activity by high frequency sinusoidal fields in rat hippocampal slices. Journal of Physiology 2001; 531:181-191 PDF
Durand DM, Bikson M. Suppression and control of epileptiform activity by electrical stimulation: a review. Proceedings of the IEEE 2001; 89:1065-1082 PDF
Ghai R, Bikson M, Durand DM. Effects of applied electric fields on low calcium epileptiform activity in the CA1 region of rat hippocampal slices. Journal of Neurophysiology 2000; 84:274-280 PDF
Bikson M, Ghai R, Baraban SC, Durand DM. Modulation of burst frequency, duration, and amplitude in the zero-Ca+2 model of epileptiform activity. Journal of Neurophysiology 1999; 82:2262-70 PDF
Media / Selected Professional Activities
Also visit CCNY Neural Engineering Group NEWS
2010 Updates in Neurorehabilitation Course at Harvard Medical School Special lecture on "Modeling effects of neuromodulatory tools." Watch the talk
(at time 2:56)
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2009/2011 Wallace H. Coulter Early Career Award "High-Density Transcranial Electrical Stimulation" Visit the spin-off 2009 International Workshop on Seizure Prediction "Modulation Seizure Permissive States With Weak Electric Fields" slides |
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2009 Design of Medical Devices Conference "High-Density Transcranial Electrical Stimulation" slides
2008 Neural Interface Conference "Rational Design of Sub-threshold Stimulation Protocols" view the talk (link, register, and link again)
Opening Lecture 2008 Third International Conference on Transcranial Magnetic and Direct Current Stimulation "From TMS to tDCS to Modulated therapies: Biophysics of electrical therapy design" slides
Experts report for Jersey Central Power & Light Company, subsidiary of FirstEnergy Corporation 2005-2007 "A review of health hazards associated with exposure to ultra low voltages"
Moderator Health Effects Group Potomac Institute for Policy Studies, 2005 Conference on Stun Devices
Consultant for Consolidated Edison of New York 2004 "A review of hazards associated with exposure to low voltage " submitted to the New York State Public Service Commission
The City College of New York/City University of New York Medical School Institutional Animal Care and Use Committee (2004-2010)
Co-director, Howard Hughes Medical Institute Program for Undergraduates at CCNY (2005-2009)
Teaching
Undergraduate
Biomedical Engineering Senior Design 1 (BME 405)
Experimental Methods in Biomedical Engineering (BME 310)
Biomedical Transducers and Instrumentaiton (BME 405)
Introduction to Biomedical Enginering (BME 101)
Graduate
Marom Bikson
Associate Professor of Biomedical Engineering
The City College of The City University of New York
Steinman Hall, T-403B
212.650.6791
212.650.6727
bikson@ccny.cuny.edu
Bikson Lab [..]