Sheldon Weinbaum

Sheldon Weinbaum

Education

B.A.E., 1959, Rensselaer Polytechnic Institute;
M.S. Applied Physics, 1960, Harvard Univ.;
Ph.D. Engineering, 1963, Harvard Univ.

Awards & Honors

One of the ten living individuals elected to all three U.S. National Academies NAS, NAE and IOM
Fellow: ASME, AIMBE, APS
Gordon McKay Prize Fellow, Harvard University (1959-1961)
NSF Fellow, Harvard University (1961-1963)
Senior Fellow Scientific Research Council of Great Britain (1974)
NSF "Special Creativity" Award (1985)
Public Service Award City of New York (1988)
Research Award of the European Society of Biomechanics (1994)
H.R.Lissner Award and Melville Medal of the ASME (1994)
Best Paper Award Bioengineering Division ASME (1995)
Melville Medal of the ASME (1996)
Whitaker Distinguished Lecture BMES (1997)
Richard Skalak memorial lecture UCSD (1999)
Classic Paper Award Heat Transfer Division ASME (2000)
Suhren Lecture Tulane University (2002)
Guggenheim Fellow in Molecular and Cellular Biology (2002)
Huck Lecture Pennsylvania State University (2004)
Inaugural Fellow, Biomedical Engineering Society (2005)
Woodruff Lecture Georgia Institute of Technology (2007)
Sackler Lecturer Tel Aviv University (2007)
Ascher H. Shapiro Lecture M.I.T. (2007)
70th Anniversary Lecture, Hong Kong Polytechnic University (2007)
Davies Medal RPI (highest honor for engineering achievement) (2008)
Beckman Distinguished Lecture, University of Illinois (2008)
Chair Bioengineering Section of the NAE (2008-2010)
Inaugural Diversity Award of the Biomedical Engineering Society (2009)
Jack Vinson Distinguished Lecture, University of Delaware (2011)
Chair Class III Temporary Nominating Group NAS (2011-2014)
"New Horizons" Lecture Clarkson University (2012)
Honorary Doctorate of Science, The City College of New York (2012)

Research Interests

Fluid dynamic and transport aspects of arterial disease, bioheat transfer, cellular mechanisms for mechanotransduction, bone fluid flow, microvascular exchange, transport in the renal tubule, basic fluid mechanics, porous media flow.
Professor Weinbaum has published more than 230 full length journal papers plus numerous shorter communications and conference papers. In the early part of his career he was widely recognized for his contributions to reentry aerodynamics and basic studies in fluid mechanics nearly 40 of which have been published in the J. Fluid Mechanics. Starting in the early 1970's he shifted his interests to transport and cellular level biomechanical phenomena in the human body. His joint studies with S. Cowin and M. Schaffler have explored the cellular transduction mechanisms by which bone cells detect mechanically induced strains and communicate these strains to the bone forming cells. His joint studies with the UC Davis (F. E. Curry and R Adamson) have attempted to elucidate the structural pathways through the interendothelial cleft that determine capillary permeability and the osmotic forces that act across vascular endothelium. This has led to a major revision of the century old Starling hypothesis. His studies with Weill-Cornell Medical School (A. Weinstein) and Yale Medical School (T. Wang) have led to a new hypothesis for the mechanosensory mechanism that leads to the glomerulotubular balance in the kidney.
His joint studies with Albert Einstein College of Medicine (D. Spray) and J. Tarbell have provided a new model for the role of the endothelial glycocalyx in transmitting fluid shear stress to the intracellular actin cytoskelton and the regulation of junctional proteins. His joint studies with the UC San Diego (S. Chien) have investigated the cellular origins of the permeability of arterial endothelium to low density lipoproteins, transport models for the arterial intima and the formation of subendothelial liposomes. These have led to the discovery at the cellular level of the endothelial pore via which LDL cholesterol crosses arterial endothelium. His studies in bioheat transfer with L. Jiji and D. Lemons have led to the development of a fundamental new bioheat equation to describe microvascular blood-tissue heat transfer (Weinbaum-Jiji equation) and the application of bioheat models to describe heat transfer in muscle tissue, human limbs, rat tail and finger.
Most recently, he has proposed a new hypothesis for vulnerable plaque rupture due to cellular level micro-calcifications in thin fibrous caps which were detected for the first time using high resolution micro-CT and a jet train which flies on a soft porous track within centimeters of the ground at speeds approaching 700km/hr. The studies on plaque rupture are conducted with L. Cardoso and the studies on the high speed train with Y. Andreopoulos.

Recent & Frequently Cited Publications

Maldonado, N., Kelly-Arnold, A., Cardoso, L., and Weinbaum, S., \"The explosive growth of small voids in vulnerable cap rupture; cavitation and interfacial debonding\", J. Biomechanics, 46, 396-401, (2013).
Causey, L., Cowin, S.C., and Weinbaum, S., \"Quantitative model for predicting lymph formation and muscle compressibility in skeletal muscle during contraction and stretch\", Proc. Nat\'l. Acad. Sci. USA 109, No. 23, 9185-9190 (2012).
Maldonado, N., Kelly-Arnold, A., Vengrenyuk, Y., Laudier, D., Fallon, J.T., Cardoso, L., and Weinbaum, S., " A mechanistic analysis of the role of microcalcifications in aherosclerotic plaque stability; potential implications for cap rupture\', Am. J. Physiol.Heart Circ. Physiol., 303, H619-H628 (2012).
Du, Z., Wan, L., Yan, Q., Weinbaum, S., Weinstein, A.M., and Wang, T., \"Regulation of glomerulotubular balance. II. Impact of angiotension II on flow-dependent transport\", Am. J. Physiol. Renal Physiol., 303, F386-F395, (2012).
Du, Z., Yan, Q., Wan, L., Weinbaum, S., Weinstein, A.M., and Wang, T., \"Regulation of glomerulotubular balance. I. Impact of dopamine on flow-dependent transport\", Am. J. Physiol. Renal Physiol., 303, F1507-F1516, (2012).
Rambhia, S.H., Liang, X., Xenos, M., Alemu, Y., Maldonado, N., Kelly, A., Chakraborti, S., Weinbaum, S., Cardoso, L., Einav, S., Bluestein, D., Miccrocalcifications increase coronary vulnerable plaque rupture potential; A patient-based micro-CT fluid-structure interaction study\", Annals. Biomed. Eng., 40, 1443-1454, (2012).
Weinbaum, S., Duan, Y., Thi, MM., You, LD “An Integrative Review of Mechanotransduction in Endothelial, Epithelial (Renal) and Dendritic Cells (Osteocytes): Cell. Molec. Bioeng., 4, 510-537 (2011).
Wu, D; Ganatos, P., Spray, DC., Weinbaum, S, “On the electrophysiological response of bone cells using a Stokesian fluid stimulus probe for delivery of quantifiable localized picoNewton level forces,” J. Biomechanics, 44,1702-1708 ( 2011).
Akaydin, HD., Pierides, A., Weinbaum, S., Andreopoulos, Y, “Permeability of soft porous media under one­dimensional compaction,” Chem. Eng. Sci., 66, 1-14 (2011).
Duan,Y., Weinstein, A.M., Weinbaum, S. and Wang, T. “Shear-induced Changes of Membrane Transporter Localization and Expression in Mouse Proximal Tubule Cells” Proc. Nat'l. Acad. Sci. USA 107, No. 50, 21860-21865 (2010).
Weinbaum, S., Duan, Y., Satlin, L.M., Wang, T. and Weinstein, A.M., “Mechanotransduction in the Renal Tubule”, Am. J. Physiol.-Renal Physiol., 299, F1220-F1236, (2010).
Vengrenyuk, Y., Kaplan, T.J., Cardoso, L. and Weinbaum, S. “Computational Stress Analysis Atherosclerotic Plaques in ApoE Knockout Mice”, Annals Biomed. Eng. 38, 738-747, (2010).
Weinbaum, S.. “Fulfilling the Dream: The Importance of Doing What You Believe and Being Taken Seriously”, Inaugural Diversity Award BMES, Annals. Biomed. Eng. 38, 1132-1140 (2010).
Fritton, S.P., Weinbaum, S. “Fluid and solute transport in bone: Flow-induced Mechanotransduction”, Annu. Rev. Fluid Mech. 41, 347-74 (2009).
Mirbod P., Andreopoulos Y. and Weinbaum S. On the generation of lift forces in random, soft porous media. J. Fluid Mech., vol. 619, 147–166. (2009).
Mirbod, P., Andreopoulos, Y., Weinbaum, S., “An Airborne Jet Train that Flies on a Soft Porous Track”, J. Porous Media 12, 1037-52 (2009).
Duan, Y., Gotoh, N., Yan, Q., Du, Z., Weinstein, A.M., Wang, T., Weinbaum, S., “Shear-induced Reorganization of Renal Proximal Tubule Cell Actin Cytoskeleton and Apical Junctional Complexes,” Proc. Nat'l. Acad. Sci. USA 105, No. 31, 11418-11423, (2008).
Zhang, X., Adamson, R.H., Curry, F.E., Weinbaum, S., “Transient Regulation of Transport by Pericytes in venular Microvessles via Trapped Microdomains,” Proc. Nat'l. Acad. Sci. USA 105, No. 4, 1374-1379, (2008).
Wang, Y., McNamara, L. M., Schaffler, M. B., Weinbaum, S., “A Model for the Role of Integrins in Flow Induced Mechanotransduction in Osteocytes,” Proc. Nat'l. Acad. Sci. USA, 104, No. 40, 15941-15946, (2007).
Weinbaum, S., Tarbell, M. J., Damiano, E. R., “The Structure and Function of the Endothelial Glycocalyx Layer,” Annu. Rev. Biomed. Eng., 9, 121-167, (2007).
Vengrenyuk, Y., Carlier, S., Xanthos, S., Cardoso, L., Ganatos, P., Vermani, R., Einav, S., Gilchrist, L., Weinbaum, S., “A Hypothesis for Vulnerable Plaque Rupture due to Stress-Induced Debonding Around Cellular Microcalcifications in Thin Fibrous Caps,” Proc. Nat'l. Acad. Sci. USA, 103 No. 40, 14678-14683, (2006).
Han, Y., Cowin, S., Schaffler, M., and Weinbaum, S., "Mechanotransduction and Strain Amplification in Osteocyte Cell Processes", Proc. Nat'l. Acad. Sci. USA, 101, 16689-16994,(2004)
Thi, MM, Tarbell, J., Weinbaum, S., and Spray D., "The Role of the Glycoalyx in Reorganizationof the Actin Cytoskeleton under Fluid Shear Stress: A 'Bumper Car' Model", Proc. Nat'l. Acad. Sci. USA, 101, 16483-16488, (2004)
Du, Z, Duan, Y., Yan, Q-S, Weinstein, A. M., Weinbaum, S., Wang, T., "Mechansensory Function of Microville of the Kidney Proximal Tubule", Proc. Nat. Acad. Sci. USA, 101,13068-13073, (2004)
Wu, Q., Andreopoulos, Y. and Weinbaum, S., "From Red Cells to Snowboarding to a New Concept for Train Track", Physical Review Lett., 93, 194501 (2004)
Adamson, R. H., Lenz, J. F., Zhang, X., Adamson, G. N., Weinbaum, S. and Curry, F.E.,"Oncotic Pressures Opposing Filtration Across Non-fenestrated Rat Microvessels", J. Physiology, 557.3 889-907, (2004)
Weinbaum, S., Zhang, X., Han, Y., Vink, S., Cowin, S.C., "Mechanotransduction and FlowAcross the Endothelial Glycocalyx", Proc. Nat'l. Acad. Sci. USA, 100, 7988-7995, (2003)


Sheldon Weinbaum
CUNY Distinguished Professor of Biomedical & Mechanical Engineering The City College of The City University of New York
Steinman Hall, T-404B
212.650.5202
212.650.6727
weinbaum@ccny.cuny.edu
Weinbaum Lab [..]