John M. Tarbell
Education
B.S., Chemical Engineering, 1969,
M.S., Chemical Engineering, 1972,
Ph.D., Chemical Engineering, 1974,
Awards & Honors
Tau Beta Pi (1969), Phi Lambda Upsilon (1969), Sigma Xi (1979), National Research Service Award PHS (1983), Outstanding Teacher Award (College of Engineering 1987), Outstanding Research Award (College of Engineering 1988), Teacher of the Year (Department of Chemical Engineering, 1992), Editorial Boards: Journal of Biomechanical Engineering (1989-1995), Annals of Biomedical Engineering (1999-), Chairman of Biofluid Mechanics National Program Committee (ASME), 1989-1992, NIH Surgery and Bioengineering Study Section Member 1995-1999, Fellow of the American Institute of Medical and Biological Engineering (1996), Premier Research Award (College of Engineering, 1996), Distinguished Professor of Chemical Engineering and Bioengineering (PSU, 1998), AIMBE Board of Directors (1999), Fellow of the American Society of Mechanical Engineers (2001), President of the Biomedical Engineering Society (2002-2003), CUNY and Wallace Coulter Distinguished Professor of Biomedical Engineering (CCNY, 2003), Lissner Award from the Bioengineering Division of ASME (2004), Fellow of the Biomedical Engineering Society (2005), Medal of Excellence for Alumni Achievement in Academia (Rutgers University - 2010).
Research Interests
Dr. Tarbell's current research interests fall into four basic areas: (1) effects of fluid mechanical forces on vascular cells (endothelial cells, smooth muscle cells, fibroblasts) and cancer cells, (2) mechanotransduction, with emphasis on the role of the glycocalyx (cell surface proteoglycan layer), (3) studies of endothelial permeability including transport pathways and responses to fluid shear stress, (4) mass transfer in the artery wall, and the influence of cardiovascular mechanics.
Tarbell
Lab Website
Cardiovascular Dynamics and Biomolecular Transport Laboratory
Recent Publications
Giantsos-Adams K, Lopez-Quintero V, Kopeckova P, Kopecek J, Tarbell JM, Dull R. Study of the therapeutic benefit of cationic copolymer administration to vascular endothelium under mechanical stress. Biomaterials. 2010 Oct 5. [Epub ahead of print]
Shi ZD, Abraham G, Tarbell JM. Shear stress modulation of smooth muscle cell marker genes in 2-D and 3-D depends on mechanotransduction by heparan sulfate proteoglycans and ERK1/2. PLoS One. 2010 Aug 16;5(8). pii: e12196.
Tarbell JM. Shear stress and the endothelial transport barrier. Cardiovasc Res. 2010 Jul 15;87(2):320-30.
Li G, Simon MJ, Cancel LM, Shi ZD, Ji X, Tarbell JM, Morrison B 3rd, Fu BM. Permeability of endothelial and astrocyte cocultures: in vitro blood-brain barrier models for drug delivery studies. Ann Biomed Eng. 2010 Aug;38(8):2499-511.
Lopez-Quintero SV, Datta A, Amaya R, Elwassif M, Bikson M, Tarbell JM.
DBS-relevant electric fields increase hydraulic conductivity of in vitro
endothelial monolayers. J Neural
Cancel LM, Tarbell JM. The
role of apoptosis in
Shi ZD, Ji
XY,
Shi ZD, Ji
XY, Qazi H, Tarbell JM. Interstitial flow promotes
vascular fibroblast, myofibroblast, and smooth muscle
cell motility in 3-D collagen I via upregulation of
MMP-1. Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1225-34. Epub 2009 May
22.
Dabagh M, Jalali
P, Tarbell JM. The transport of
Lopez-Quintero
SV, Amaya R, Pahakis M, Tarbell JM. The endothelial glycocalyx
mediates shear-induced changes in hydraulic conductivity. Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1451-6.
Epub 2009 Mar 13.
Tarbell JM, Ebong EE. The endothelial glycocalyx:
a mechano-sensor and -transducer. Sci
Signal. 2008 Oct 7;1(40):pt8. Review.
Ebong, EE; Spray,
DC; Tarbell, JM.
The role of the endothelial glycocalyx
layer in transducing fluid shear stress into
intracellular signaling events. Biorheology,
45(1-2): 66-67, Published: 2008.
Phillips BE, Cancel L, Tarbell
JM, Antonetti DA. Occludin
independently regulates permeability under hydrostatic pressure and cell division
in retinal pigment epithelial cells. Invest Ophthalmol
Vis Sci. 2008 Jun;49(6):2568-76. Epub
2008 Feb 8.
Tada S, Dong C, Tarbell JM. Effect of the stress phase angle on the strain energy density of the endothelial plasma membrane. Biophys J. 2007 Nov 1;93(9):3026-33.
Dancu MB, Berardi DE, Vanden
Heuvel JP, Tarbell JM. Atherogenic
Endothelial Cell eNOS and
ET-1 Responses to Asynchronous Hemodynamics
are Mitigated by Conjugated Linoleic Acid. Ann Biomed
Cancel
LM, Fitting A, Tarbell JM. In Vitro Study of
Garanich
JS,
Weinbaum S, Tarbell JM, Damiano
ER. The Structure and Function of the
Endothelial Glycocalyx Layer. Annu
Rev Biomed
Pahakis MY, Kosky JR, Dull RO, Tarbell JM.The role of endothelial glycocalyx components in mechanotransduction of fluid shear stress. Biochem Biophys Res Commun. 2007 Mar 30;355(1):228-33.
Tada
S, Tarbell JM. Oxygen
mass transport in a compliant carotid bifurcation model. Ann Biomed
Dancu MB, Tarbell JM. Coronary endothelium expresses a pathologic gene pattern compared to aortic endothelium: Correlation of asynchronous hemodynamics and pathology in vivo. Atherosclerosis. 2006 Jun 23
Dancu MB, Tarbell
JM. Large Negative Stress Phase Angle (
Tarbell JM, Pahakis MY. Mechanotransduction and the glycocalyx. J Intern
Med. 2006 Apr;259(4):339-50. Review.
Garanich JS, Pahakis M, Tarbell JM. Shear stress inhibits smooth muscle cell migration via the nitric oxide-mediated downregulation of matrix metalloproteinase-2 activity. Am J Physiol Heart Circ Physiol. 2005 May;288(5):H2244-52.
Tarbell JM, Weinbaum S, Kamm
RD. Cellular fluid mechanics and mechanotransduction.
Ann Biomed
Tada
S, Tarbell JM. A computational study of flow in a
compliant carotid bifurcation-stress phase angle correlation with shear stress.
Ann Biomed Eng. 2005 Sep;33(9):1202-12.
Pang Z, Antonetti DA, Tarbell JM. Shear stress regulates
HUVEC hydraulic conductivity by occludin phosphorylation.
Ann Biomed
Kim MH, Harris NR, Tarbell JM. Regulation of hydraulic conductivity in response to sustained changes in pressure. Am J Physiol Heart Circ Physiol. 2005 Aug 19.
Kim MH, Harris NR, Tarbell JM. Regulation of capillary hydraulic conductivity in response to an acute change in shear. Am J Physiol Heart Circ Physiol. 2005 Jul 1.
Ainslie KM, Garanich JS, Dull RO, Tarbell JM. Vascular smooth muscle cell glycocalyx influences shear stress-mediated contractile response. J Appl Physiol. 2005 Jan;98(1):242-9.
Ainslie
KM, Shi ZD, Garanich JS, Tarbell JM. Rat aortic
smooth muscle cells contract in response to serum and its components in a
calcium independent manner. Ann Biomed
Tada S, Tarbell JM. Internal elastic lamina affects the distribution of macromolecules in the arterial wall: a computational study. Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H905-13.
Kim MH, Harris NR, Korzick DH, Tarbell JM. Control of the arteriolar myogenic response by transvascular fluid filtration. Microvasc Res.68(1):30-7. (2004)
Thi MM, Tarbell
JM, Weinbaum S,
Dancu MB, Berardi DE, Vanden Heuvel JP, Tarbell JM. Asynchronous Shear Stress and Circumferential Strain Reduces Endothelial NO Synthase and Cyclooxygenase-2 but Induces Endothelin-1 Gene Expression in Endothelial Cells. Arterioscler Thromb Vasc Biol. 2004 Sep 2
DeMaio L, Antonetti DA, Scaduto RC Jr, Gardner TW, Tarbell JM. VEGF increases paracellular transport without altering the solvent-drag reflection coefficient. Microvasc Res. 2004 Nov;68(3):295-302.
DeMaio L, Tarbell JM, Schwartz CJ, Gardner TW, Antonetti DA. A Transmural Pressure Gradient Induces Mechanical and Biological Adaptive Responses in Endothelial Cells. American Journal of Physiology: Heart and Circulatory Physiology. 2004;286:H731-H741.
John M. Tarbell
CUNY and Wallace Coulter Distinguished Professor of Biomedical Engineering
The City College of The City University of New York
Steinman Hall, T-404B
212.650.6841
212.650.6727
tarbell@ccny.cuny.edu