Bingmei Fu

Education

Postdoc, Department of Human Physiology, School of Medicine, University of California, Davis, 1995-1998

Ph.D. Mechanical Engineering, The City University of New York, 1995

M.Eng. Modern Mechanics, University of Science & Technology of China, 1988

B.S. Modern Mechanics, University of Science & Technology of China, 1985

Prefessional Experience

Professor, 2010-
Associate Professor, 2004-2010
Department of Biomedical Engineering
The City College of the City University of New York

Assistant-Associate Professor, 1998-2004
Department of Mechanical Engineering
Howard R. Hughes College of Engineering
University of Nevada, Las Vegas

Assistant Professor, 1988-1989
Department of Engineering Mechanics
Southwest Jiao Tong University, China

Selected Awards & Honors

2012 Fellow, American Institute For Medical and Biological Engineering

2002-2003 Distinguished Research Award
Howard R. Hughes College of Engineering, University of Nevada, Las Vegas

2002-2008 Career Award, NSF

1996-1998 Postdoctoral Fellowship
NIH Training Grant in Cardiology and Neurophysiology

1996 Harold Shames Biomedical Engineering Award for Graduate Excellence in Research
New York Center for Biomedical Engineering Consortium

1995 Whitaker Graduate Student Award for Best Paper
Biomedical Engineering Society

Selected Student Awards from the Fu Lab

Okworogwo, J.C., Feng, SS, Fu, BM. Hyperthermia Can Enhance The Delivery And Effect Of Paclitaxel-Loaded Poly(lactide) -Tocopheryl Polyethylene Glycol Succinate (PLA-TPGS) Formulated Nanoparticles
Grand Prize for Poster Presentation
The Empire State Medical Association Annual Conference, New York Academy of Medicine, Nov. 1, 2008, New York

Cai,B.,Fan,J.,Zeng,M., and Fu, B.M. Effects of VEGF on MDA-MB-435s cancer cell adhesion to microvessel walls in vivo
Best Poster Award
Northeast Biomedical Engineering Annual Conference, March 26-28, 2010, New York

Research Interests

Molecular, Cell and Tissue Engineering in the Microcirculation

Modeling nano-micro transport phenomena in transvascular, transcelluar and transinterstitial processes

Structural mechanisms of acute increase of microvessel permeability

Tumor migration and metastasis in vivo

In vivo permeability studies on single microvessel
(microperfusion, quantitative video microscopy, fluorescence microscope photometry and confocal microscopy, image processing)

Regulation of vessel permeability by mechanical, physical and chemical stimuli
(signal transduction, permeability studies under physiological and pathological conditions)

Drug delivery to brain through the Blood-Brain Barrier and the CSF

Mechano-sensing and transduction in the microcirculation

Optimization in therapeudic medical device

Fluid Mechanics, Mass and Heat Transfer

Recent & Frequently Cited Publications

Fu, BM and Tarbell JM. Mechano-sensing and transduction by endothelial surface glycocalyx: composition, structure and function. in “Endothelial mechanobiology: computational and experimental methods” in Systems Biology in Medicine and Biology (invited). accepted, 2013.

Fan, J., Jia, X., Huang,Y., Fu, BM and Fan, Y.Higher Scaffold Permeability Promotes the Growth of Osteoblastic Cells in a Perfused Bioreactor. J. of Tissue Eng. and Regenerative Medicine, accepted, 2013.

Zeng Y, Ebong EE, Fu BM, Tarbell JM. The structural stability of the endothelial glycocalyx after enzymatic removal of glycosaminoglycans. PLoS one. 2012;7(8):e43168. Epub 2012.

Cai, B, Fan, J., Zeng, M., Zhang, L. and Fu, B.M. Adhesion of malignant mammary tumor cell MDA-MB-231 to microvessel wall increases microvascular permeability via degradation of endothelial surface glycocalyx. J. of Appl. Physiol. 13(7):1141-53, 2012.

Guo, P. and Fu, B.M. Effect of Wall Compliance and Permeability on Blood Flow Rate in Counter-current Microvessels Formed from Anastomosis during Tumor Induced Angiogenesis. ASME, J. of Biomech. Eng., 134(4):041003, 2012.

Yen, W., Cai, B., Zeng, M., Tarbell, J.M. and Fu, B.M. Quantification of endothelial glycocalyx layer in rat and mouse blood vessels. Microvas. Res, 83: 337-346, 2012.

Fu, B.M. and Liu, Y. Microvascular transport and tumor cell adhesion in the microcirculation. Ann. of Biomed. Eng., 40(11):2442-55, 2012.

Fu, B.M. Non-invasive delivery of iRNAs, proteins, peptides, cytokines and nanoparticles. Current Pharm. Biotech., 13(7):1278, 2012. (Editorial)

Fu, B. M. Experimental Methods and Transport Models for Drug Delivery across the Blood-Brain Barrier. Current Pharm. Biotech., 13(7):1346-59, 2012.

Yan W, Cai, B., Liu, Y, and Fu, B.M. Effect of wall shear stress and its gradient on tumor cell adhesion in curved microvessels. Biomechanics and Modeling in Mechanobiology, 11:641-653, 2012.

Fan, J., Cai, B, Zeng, M., Hao, Y., Giancotti, F. and Fu, B.M. Integrin β4 signaling promotes mammary tumor cell adhesion to brain microvascular endothelium by inducing ErbB2-medicated secretion of VEGF. Ann of Biomed. Eng.,39(8):2223-41, 2011.

Li, G. and Fu, B.M. An Electro-diffusion Model for the Blood-Brain Barrier Permeability to Charged Molecules. ASME J. of Biomechanical Engineering 133(2): 0210, 2011.

Liu, Q., Zeng, M. and Fu, B.M. Microvascular hyperpermeability and thrombosis induced by light/dye treatment. Biomechanics and Modeling in Mechanobiology, 10:235-47, 2011.

Yan W.W., Liu Y. and Fu, B.M. Effects of curvature and cell-cell interaction on cell arrest and adhesion in microvessels. Biomechanics and Modeling in Mechanobiology, 9(5):629-40, 2010.

Li, G., Yuan, W. and Fu, B.M. A Model for Water and Solute Transport across the Blood-Brain Barrier. J. of Biomechanics, 43(11): 2133-40,2010[PDF].

Yuan W. Li, G., Zeng, M. and Fu, B.M. Modulation of the Blood-brain barrier permeability by plasma glycoprotein orosomucoid. Microvasc. Res., 80(1):148-157, 2010[PDF].

Li, G., Simon, M., Shi, Z, Cancel, L, Tarbell, J., Morrison, B. and Fu, B.M. Permeability of endothelial and astrocyte cocultures: in vitro blood-brain barrier models for drug delivery. Ann. of Biomed. Eng, 38(8):2499-2511, 2010. (Cover) [PDF].

Yuan W, Li, G, Gil, ES,Lowe, TL, and Fu, B.M. Effect of Surface Charge of Immortalized Mouse Cerebral Endothelial Cell Monolayer on Transport of Charged Solutes. Annals of Biomedical Engineering, 38(4):1463-72, 2010.[PDF].

Shen, S., Fan, J. Cai, B., Lv, Y., Zeng, M., Hao, Y., Giancotti, F. and Fu, B.M. Vascular Endothelial Growth Factor Enhances Mammary Cancer Cell Adhesion to Endothelium in vivo. J. of Exp. Physiology, 95:369-379, 2010.[PDF].

Chen, B. and Fu, B.M. A time-dependent electrodiffusion-convection model for charged macromolecule transport across the microvessel wall and in the interstitial space. Cellular and Molecular Bioengineering, 2(4): 514-532, 2009.[PDF].

Lv, Y., Cheung, NK. V., and Fu, B.M. A Pharmacokinetic model for radioimmunotherapy delivered through cerebrospinal fluid for the treatment of leptomeningeal metastases. J. of Nuclear Medicine. 50(8): 1324-1331, 2009.[PDF].

Yuan, W. Lv, Y. Zeng, M. and Fu, B.M. Non-invasive measurement of solute permeability in cerebral microvessels of the rat. Microvas. Res., 77:166-173, 2009[PDF].

Chen, X.Y., Liu, Y. Fu, B.M., Fan, J.T., and Yang, J.M. MD simulation of colloidal particle transportation in a fiber matrix. Mol. and Cel. Biomechanics. 5(4):275-284, 2008.[PDF].

Liu, Q. Mirc D. and Fu, B.M. Mechanical mechanisms of thrombosis in intact bent microvessels of rat mesentery. J. of Biomechanics. 41: 2726-2734, 2008.[PDF].

Fu, B. M., Shen, S. and Chen, B. Structural Mechanisms in the Abolishment of VEGF-induced Microvascular Hyperpermeability by cAMP. ASME J. Biomech. Eng., 128(3):313-328, 2006.[PDF].

Sugihara-Seki,M. and Fu, B.M. Blood Flow and Permeability in Microvessels, Fluid Dynamics Research, 37:82-132, 2005.[PDF].

Ma, J., Guo, P., Zhang, J. Li, N. and Fu, B.M. Enhancement of Oxygen Transfer in Liquid Lead and Lead-bismuth Eutectic by Natural Convection. Int. J. of Heat and Mass Transfer, 48:2601-2612, 2005.[PDF].

Chen, B., Yee, T., Kiser, M. A. and Fu, B.M. A Multidimensional Optimization Process for Enhancing Electroacupuncture Efficiency. Medical Acupuncture, Vo. 16 (2):12-19, 2005.[PDF].

Fu, B. M., Adamson, R.H. and Curry, F.E. Determination of Microvessel Permeability and Tissue Diffusion Coefficient by Laser Scanning Confocal Microscopy. ASME J. Biomech. Eng. 127(2):270-278, 2005.[PDF].

Chen, B. and Fu, B.M. An Electrodiffusion-Filtration Model for Effects of Surface Glycocalyx on Microvessel Permeability to Macromolecules. ASME J. Biomech. Eng., 126:614-624, 2004.[PDF].

Yan, H., Jiang, Y. T., Zheng, J., Fu, B.M. , Shao, S., Peng, C. The internet-based knowledge acquisition and management method to construct large-scale distributed medical expert systems. Comp. Methods and Programs in Biomedicine, 74, 1-10, 2004 [PDF].

Fu, B.M. and Shen, S. Acute VEGF effect on solute permeability of mammalian microvessels in vivo. Microvasc Res., 68(1):51-62, 2004 [PDF].

Fu, B.M. , and Chen, B. A Model for the Modulation of Microvessel Permeability by Junction Strands. ASME J. Biomech. Eng., Vol 125, 620-627, 2003 [PDF].

Guo, P., Hillyard, S.D., and Fu, B.M. A Two-Barrier Compartment Model for Volume Flow across Amphibian Skin. Am. J. of Physiol., 285, R1384-1394, 2003 [PDF].

Fu, B.M. and Shen, S. Structural mechanisms of vascular endothelial growth factor (VEGF) on microvessel permeability. Am J Physiol; 284(6): H2124-2135, 2003 [PDF].

Fu, B.M., Chen, B, and Chen, W. An Electrodiffusion Model for Effects of Surface Glycocalyx Layer on Microvessel Solute Permeability. Am. J. Physiol. 284: H1240-1250, 2003 [PDF].

Fu, B.M., Adamson, R.H., and Curry, F.E., Test of a two pathway model for small solute exchange across capillary wall.Am. J. Physiol. 274 (43): H2062-H2073, 1998 [PDF].

Fu, B., Curry, F.E., Adamson, R.H., and Weinbaum S. A model for interpreting the labeling of interendothelial clefts. Ann. Biomed. Eng. 25(2):375-397, 1997.[PDF].

Fu, B.M., Curry, F.E., and Weinbaum, S. A diffusion wake model for tracer ultrastructure-permeability studies in microvessels. Am. J. Physiol. 269(38): H2124-H2140, 1995.[PDF].

Fu, B.M., Tsay, R., Curry, F.E., and Weinbaum, S. A junction-orifice-entrance layer model for capillary permeability: Application to frog mesenteric capillaries. ASME J. Biomech. Eng. 116: 502-513, 1994. [PDF].